Radiation therapy is one of the major tools of cancer treatment, and is widely used for a
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …

The current preclinical and clinical findings demonstrate that, in addition to the conventional
clinical and pathological indicators that have a prognostic value in radiation oncology, the …

The appearance and growth of malignant tumors is a complicated process that is regulated
by a number of genes. In recent years, studies have revealed that the transforming growth …

Transforming growth factor beta (TGF-β) plays key roles in regulating cellular proliferation
and maintaining tissue homeostasis. TGF-β exerts tumor-suppressive effects in the early …

The epithelial-to-mesenchymal transition (EMT) is a trans-differentiation process that
endows epithelial cells with mesenchymal properties, including motility and invasion …

Cancer is a dysregulated cellular level pathological condition that results in tumor formation
followed by metastasis. In the heterogeneous tumor architecture, cancer stem cells (CSCs) …

Cisplatin is a first line chemotherapy in lung cancer, but decreased susceptibility may limit its
application. In solid tumors, hypoxia alters the microenvironment and is associated with …

Purpose Gastric cancer (GC) has high morbidity and mortality and is a serious threat to
public health. The flavonoid compound vitexin is known to exhibit anti-tumor activity. In this …

Studies have demonstrated low expression of miR-145 associated with cell proliferation and
migration in a wide variety of tumors. Here, we studied the expression of miR-145 in relation …

Endometriosis is an estrogen-dependent benign gynecological disease that shares some
common features of malignancy. Epithelial–mesenchymal transition (EMT) has been …