Ageing is a plastic process and can be successfully modulated by some biomedical
approaches or pharmaceutics. In this manner it is possible to delay or even prevent some …

Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …

Aging of organisms begins from a single cell at the molecular level. It includes changes
related to telomere shortening, cell senescence and epigenetic modifications. These …

Sirtuins are evolutionarily conserved nicotinamide adenine dinucleotide (NAD+)-dependent
lysine deacylases or ADP-ribosyltransferases. These cellular enzymes are metabolic …

Sirtuins (SIRTs), class III histone deacetylases, are differentially expressed in several human
cancers, where they display both oncogenic and tumor-suppressive properties depending …

Among the greatest challenges facing organisms is that of detecting and effectively
responding to life-threatening environmental changes that are intimately associated with …

The establishment of the epigenetic mark H4K20me1 (monomethylation of H4K20) by PR-
Set7 during G2/M directly impacts S-phase progression and genome stability. However, the …

Hypoxia (low O 2) is an essential microenvironmental driver of phenotypic diversity in
human solid cancers. Hypoxic cancer cells hijack evolutionarily conserved, O 2-sensitive …

Abstract The sirtuins (SIRT 1–7) comprise a family of NAD+-dependent protein-modifying
enzymes with activities in lysine deacetylation, adenosinediphospho (ADP)-ribosylation …

Epigenetic inactivation of pivotal genes involved in correct cell growth is a hallmark of
human pathologies, in particular cancer. These epigenetic mechanisms, including crosstalk …