The comparative toxicogenomics database: update 2019

AP Davis, CJ Grondin, RJ Johnson… - Nucleic acids …, 2019 - academic.oup.com
Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) is a premier
public resource for literature-based, manually curated associations between chemicals …

The comparative toxicogenomics database: update 2013

AP Davis, CG Murphy, R Johnson, JM Lay… - Nucleic acids …, 2013 - academic.oup.com
Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) provides
information about interactions between environmental chemicals and gene products and …

MEDIC: a practical disease vocabulary used at the Comparative Toxicogenomics Database

AP Davis, TC Wiegers, MC Rosenstein, CJ Mattingly - Database, 2012 - academic.oup.com
Abstract The Comparative Toxicogenomics Database (CTD) is a public resource that
promotes understanding about the effects of environmental chemicals on human health …

A CTD–Pfizer collaboration: manual curation of 88 000 scientific articles text mined for drug–disease and drug–phenotype interactions

AP Davis, TC Wiegers, PM Roberts, BL King, JM Lay… - Database, 2013 - academic.oup.com
Improving the prediction of chemical toxicity is a goal common to both environmental health
research and pharmaceutical drug development. To improve safety detection assays, it is …

Gene-environment interactions within a precision environmental health framework

AA Motsinger-Reif, DM Reif, FS Akhtari, JS House… - Cell Genomics, 2024 - cell.com
Understanding the complex interplay of genetic and environmental factors in disease
etiology and the role of gene-environment interactions (GEIs) across human development …

DisSim: an online system for exploring significant similar diseases and exhibiting potential therapeutic drugs

L Cheng, Y Jiang, Z Wang, H Shi, J Sun, H Yang… - Scientific reports, 2016 - nature.com
The similarity of pair-wise diseases reveals the molecular relationships between them. For
example, similar diseases have the potential to be treated by common therapeutic chemicals …

DisGeReExT: a knowledge discovery system for exploration of disease–gene associations through large-scale literature-wide analysis study

B Bhasuran, J Natarajan - Knowledge and Information Systems, 2023 - Springer
Objective Advanced experimental methods such as next-generation sequencing (NGS)
produced a large number of potential indicative genetic biomarkers and gene variants to …

Generating gene ontology-disease inferences to explore mechanisms of human disease at the comparative toxicogenomics database

AP Davis, TC Wiegers, BL King, J Wiegers… - PLoS …, 2016 - journals.plos.org
Strategies for discovering common molecular events among disparate diseases hold
promise for improving understanding of disease etiology and expanding treatment options …

Genome-scale meta-analysis of breast cancer datasets identifies promising targets for drug development

R Altaf, H Nadeem, MM Babar, U Ilyas… - Journal of Biological …, 2021 - Springer
Background Because of the highly heterogeneous nature of breast cancer, each subtype
differs in response to several treatment regimens. This has limited the therapeutic options for …

[HTML][HTML] Environment-Gene interaction in common complex diseases: New approaches

WA Toscano, H Sehgal, E Yang, L Spaude… - AIMS Molecular …, 2014 - aimspress.com
Approximately 100,000 different environmental chemicals that are in use as high production
volume chemicals confront us in our daily lives. Many of the chemicals we encounter are …