100 years of Mycobacterium bovis bacille Calmette-Guérin

C Lange, P Aaby, MA Behr, PR Donald… - The Lancet Infectious …, 2022 - thelancet.com
Summary Mycobacterium bovis bacille Calmette-Guérin (BCG), an experimental vaccine
designed to protect cattle from bovine tuberculosis, was administered for the first time to a …

[HTML][HTML] BCG-induced cross-protection and development of trained immunity: implication for vaccine design

C Covián, A Fernández-Fierro, A Retamal-Díaz… - Frontiers in …, 2019 - frontiersin.org
The Bacillus Calmette-Guérin (BCG) is a live attenuated tuberculosis vaccine that has the
ability to induce non-specific cross-protection against pathogens that might be unrelated to …

[PDF][PDF] BCG vaccination protects against experimental viral infection in humans through the induction of cytokines associated with trained immunity

RJW Arts, SJ Moorlag, B Novakovic, Y Li, SY Wang… - Cell host & …, 2018 - cell.com
The tuberculosis vaccine bacillus Calmette-Guérin (BCG) has heterologous beneficial
effects against non-related infections. The basis of these effects has been poorly explored in …

[PDF][PDF] WHO operational handbook on tuberculosis: module 2: screening: systematic screening for tuberculosis disease

World Health Organization - 2021 - apps.who.int
The two complementary approaches for improving early detection of TB are illustrated in Fig.
2.1 The primary approach is to optimize the patient-initiated pathway to TB diagnosis and …

Different drugs for bad bugs: antivirulence strategies in the age of antibiotic resistance

SW Dickey, GYC Cheung, M Otto - Nature Reviews Drug Discovery, 2017 - nature.com
The rapid evolution and dissemination of antibiotic resistance among bacterial pathogens
are outpacing the development of new antibiotics, but antivirulence agents provide an …

Mandated Bacillus Calmette-Guérin (BCG) vaccination predicts flattened curves for the spread of COVID-19

MK Berg, Q Yu, CE Salvador, I Melani, S Kitayama - Science advances, 2020 - science.org
Bacillus Calmette-Guérin (BCG) vaccination may reduce the risk of a range of infectious
diseases, and if so, it could protect against coronavirus disease 2019 (COVID-19). Here, we …

Immunology of Mycobacterium tuberculosis Infections

JK Sia, J Rengarajan - Microbiology spectrum, 2019 - Am Soc Microbiol
Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

[PDF][PDF] Immunometabolic pathways in BCG-induced trained immunity

RJW Arts, A Carvalho, C La Rocca, C Palma… - Cell reports, 2016 - cell.com
The protective effects of the tuberculosis vaccine Bacillus Calmette-Guerin (BCG) on
unrelated infections are thought to be mediated by long-term metabolic changes and …

Protection by BCG vaccine against tuberculosis: a systematic review of randomized controlled trials

P Mangtani, I Abubakar, C Ariti… - Clinical infectious …, 2014 - academic.oup.com
Background. Randomized trials assessing BCG vaccine protection against tuberculosis
have widely varying results, for reasons that are not well understood. Methods. We …

Effect of BCG vaccination against Mycobacterium tuberculosis infection in children: systematic review and meta-analysis

A Roy, M Eisenhut, RJ Harris, LC Rodrigues, S Sridhar… - Bmj, 2014 - bmj.com
Objectives To determine whether BCG vaccination protects against Mycobacterium
tuberculosis infection as assessed by interferon γ release assays (IGRA) in children. Design …