The balance between ATR and DDK activities controls TopBP1-mediated locking of dormant origins at the pre-IC stage
S Koundrioukoff, SJ Kim, N Alary, A Toffano… - bioRxiv, 2023 - biorxiv.org
Replication stress, a major hallmark of cancers, and ensuing genome instability source from
impaired progression of replication forks. The first line of defense against fork slowing is …
impaired progression of replication forks. The first line of defense against fork slowing is …
Human DNA replication initiation sites are specified epigenetically by oxidation of 5-methyl-deoxycytidine
T Krude, J Bi, R Doran, RA Jones, JC Smith - bioRxiv, 2024 - biorxiv.org
DNA replication initiates at tens of thousands of sites on the human genome during each S
phase. However, no consensus DNA sequence has been found that specifies the locations …
phase. However, no consensus DNA sequence has been found that specifies the locations …
Nuclear DNA replication in Leishmania major relies on a single constitutive origin per chromosome supplemented by thousands of stochastic initiation events
JD Damasceno, GLA Silva, CA Marques… - bioRxiv, 2024 - biorxiv.org
Understanding genome duplication requires characterisation of the locations where DNA
replication initiates, termed origins. Genome-wide mapping of DNA replication origins has …
replication initiates, termed origins. Genome-wide mapping of DNA replication origins has …
Regulation of replication timing in Saccharomyces cerevisiae
R Berners-Lee, E Gilmore, F Berkemeier, MA Boemo - bioRxiv, 2024 - biorxiv.org
In order to maintain genomic integrity, DNA replication must be highly coordinated.
Disruptions in this process can cause replication stress which is aberrant in many …
Disruptions in this process can cause replication stress which is aberrant in many …
ATR and TopBP1 oppose to control dormant origin building, providing a first defence against replication stress
M Debatisse, S Koundrioukoff, S Kim, N Alary… - 2024 - researchsquare.com
Replication stress, a major hallmark of cancers, sources from replication fork slowing or
blocking. In response, activation of extra-origins, otherwise dormant, supports the replication …
blocking. In response, activation of extra-origins, otherwise dormant, supports the replication …