This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Hepatotoxicity is a serious problem during drug development and for the use of many
established drugs. For example, acetaminophen overdose is currently the most frequent …

Development of idiosyncratic hepatotoxicity is an intricate process involving both concurrent
as well as sequential events determining the direction of the pathways, degree of liver injury …

Acute liver failure is a rare disorder with high mortality and resource cost. In the developing
world, viral causes predominate, with hepatitis E infection recognised as a common cause in …

Idiosyncratic drug-induced liver injury (DILI) is a type of hepatic injury caused by an
uncommon drug adverse reaction that can develop to conditions spanning from …

Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause
liver injury and even liver failure. INH metabolism has been thought to be associated with …

Numerous investigations have shown that mitochondrial dysfunction is a major mechanism
of drug-induced liver injury, which involves the parent drug or a reactive metabolite …

Isoniazid (INH) remains a mainstay for the treatment of tuberculosis despite the fact that it
can cause liver failure. Previous mechanistic hypotheses have classified this type of drug …

Idiosyncratic drug-induced liver injury (DILI) is a common cause for drug withdrawal from the
market and although infrequent, DILI can result in serious clinical outcomes including acute …

Drug-induced liver injury (DILI) has become a leading cause of severe liver disease in
Western countries and therefore poses a major clinical and regulatory challenge. Whereas …