Tau neuronal and glial pathologies drive the clinical presentation of Alzheimer's disease
and related human tauopathies. There is a growing body of evidence indicating that …

Tau is a microtubule-associated protein with versatile functions in the dynamic assembly of
the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative …

In tauopathies, abnormal deposition of intracellular tau protein followed by gradual elevation
of tau in cerebrospinal fluids and neuronal loss has been documented, however, the …

Although the mechanisms of toxic activity of tau are not fully recognized, it is supposed that
the tau toxicity is related rather not to insoluble tau aggregates but to its intermediate forms. It …

The human tau protein is implicated in a wide range of neurodegenerative “tauopathy”
diseases, consisting of Alzheimer's disease (AD) and frontotemporal lobar degeneration …

With predictions showing that 131.5 million people worldwide will be living with dementia by
2050, an understanding of the molecular mechanisms underpinning disease is crucial in the …

MicroRNAs (miRNA) regulate fundamental biological processes, including neuronal
plasticity, stress response, and survival. Here, we describe a neuroprotective function of miR …

The aggregation and accumulation of amyloidogenic peptides and proteins are observed as
pathological features in the brains of patients suffering from neurodegenerative disorders …

Introduction Extracellular tau is hypothesized to mediate the onset and progression of
tauopathies, including Alzheimer's disease, progressive supranuclear palsy, and a subset of …

Amyloid beta (Aβ) peptide, one of the most important pathogenic traits of Alzheimer's
disease (AD), invokes a cascade of oxidative damage and eventually leads to neuronal …