The impact of disease comorbidities in Alzheimer's disease
JA Santiago, JA Potashkin - Frontiers in aging neuroscience, 2021 - frontiersin.org
A wide range of comorbid diseases is associated with Alzheimer's disease (AD), the most
common neurodegenerative disease worldwide. Evidence from clinical and molecular …
common neurodegenerative disease worldwide. Evidence from clinical and molecular …
Neuroinflammation represents a common theme amongst genetic and environmental risk factors for Alzheimer and Parkinson diseases
RJ Boyd, D Avramopoulos, LL Jantzie… - Journal of …, 2022 - Springer
Multifactorial diseases are characterized by inter-individual variation in etiology, age of
onset, and penetrance. These diseases tend to be relatively common and arise from the …
onset, and penetrance. These diseases tend to be relatively common and arise from the …
Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease
C Venegas, S Kumar, BS Franklin, T Dierkes… - Nature, 2017 - nature.com
The spreading of pathology within and between brain areas is a hallmark of
neurodegenerative disorders. In patients with Alzheimer's disease, deposition of amyloid-β …
neurodegenerative disorders. In patients with Alzheimer's disease, deposition of amyloid-β …
Anti–tumor necrosis factor therapy and incidence of Parkinson disease among patients with inflammatory bowel disease
I Peter, M Dubinsky, S Bressman, A Park, C Lu… - JAMA …, 2018 - jamanetwork.com
Importance Despite established genetic and pathophysiologic links between inflammatory
bowel disease (IBD) and Parkinson disease (PD), clinical data supporting this association …
bowel disease (IBD) and Parkinson disease (PD), clinical data supporting this association …
[HTML][HTML] Pathophysiologic relationship between Alzheimer's disease, cerebrovascular disease, and cardiovascular risk: a review and synthesis
As the population ages due to demographic trends and gains in life expectancy, the
incidence and prevalence of dementia increases, and the need to understand the etiology …
incidence and prevalence of dementia increases, and the need to understand the etiology …
Peripheral immune system in aging and Alzheimer's disease
W Cao, H Zheng - Molecular neurodegeneration, 2018 - Springer
Alzheimer's disease (AD) represents an urgent public health mandate. AD is no longer
considered a neural-centric disease; rather, a plethora of recent studies strongly implicate a …
considered a neural-centric disease; rather, a plethora of recent studies strongly implicate a …
Genome-wide pleiotropy between Parkinson disease and autoimmune diseases
Importance Recent genome-wide association studies (GWAS) and pathway analyses
supported long-standing observations of an association between immune-mediated …
supported long-standing observations of an association between immune-mediated …
Discovery of shared genomic loci using the conditional false discovery rate approach
In recent years, genome-wide association study (GWAS) sample sizes have become larger,
the statistical power has improved and thousands of trait-associated variants have been …
the statistical power has improved and thousands of trait-associated variants have been …
[HTML][HTML] Biomarkers for the early detection and progression of Alzheimer's disease
The recent failures of potential disease-modifying drugs for Alzheimer's disease (AD) may
reflect the fact that the enrolled participants in clinical trials are already too advanced to …
reflect the fact that the enrolled participants in clinical trials are already too advanced to …
Understanding Alzheimer disease at the interface between genetics and transcriptomics
J Verheijen, K Sleegers - Trends in Genetics, 2018 - cell.com
Over 25 genes are known to affect the risk of developing Alzheimer disease (AD), the most
common neurodegenerative dementia. However, mechanistic insights and improved …
common neurodegenerative dementia. However, mechanistic insights and improved …