A wide range of comorbid diseases is associated with Alzheimer's disease (AD), the most
common neurodegenerative disease worldwide. Evidence from clinical and molecular …

Multifactorial diseases are characterized by inter-individual variation in etiology, age of
onset, and penetrance. These diseases tend to be relatively common and arise from the …

The spreading of pathology within and between brain areas is a hallmark of
neurodegenerative disorders. In patients with Alzheimer's disease, deposition of amyloid-β …

Importance Despite established genetic and pathophysiologic links between inflammatory
bowel disease (IBD) and Parkinson disease (PD), clinical data supporting this association …

As the population ages due to demographic trends and gains in life expectancy, the
incidence and prevalence of dementia increases, and the need to understand the etiology …

Alzheimer's disease (AD) represents an urgent public health mandate. AD is no longer
considered a neural-centric disease; rather, a plethora of recent studies strongly implicate a …

Importance Recent genome-wide association studies (GWAS) and pathway analyses
supported long-standing observations of an association between immune-mediated …

In recent years, genome-wide association study (GWAS) sample sizes have become larger,
the statistical power has improved and thousands of trait-associated variants have been …

The recent failures of potential disease-modifying drugs for Alzheimer's disease (AD) may
reflect the fact that the enrolled participants in clinical trials are already too advanced to …

Over 25 genes are known to affect the risk of developing Alzheimer disease (AD), the most
common neurodegenerative dementia. However, mechanistic insights and improved …