The adeno-associated virus (AAV) is a small, nonpathogenic parvovirus, which depends on
helper factors to replicate. Those helper factors can be provided by coinfecting helper …

Viruses threaten humans, livestock, and plants, and are difficult to combat. Imaging of
viruses by light microscopy is key to uncover the nature of known and emerging viruses in …

Recombinant adeno‐associated virus (rAAV) has established itself as a highly efficacious
gene delivery vector with a well characterised safety profile allowing broad clinical …

Recent clinical successes have propelled recombinant adeno-associated virus vectors
(rAAV) to the center stage for human gene therapy applications. However, the exploding …

Nucleoli are membrane-less structures located within the nucleus and are known to be
involved in many cellular functions, including stress response and cell cycle regulation …

Recombinant adeno‐associated virus (rAAV) is among the most commonly used vectors for
gene therapy. It is commonly produced by transfection of HEK293 cells with three plasmids …

We describe a genome-wide screening strategy to identify target genes whose modulation
increases the capacity of a cell to produce recombinant adeno-associated viral (AAV) vector …

We determined the transcription profile of adeno-associated virus type 2 (AAV2)-infected
primary human fibroblasts. Subsequent analysis revealed that cells respond to AAV infection …

The increasing demand for adeno-associated virus (AAV) vectors, a result from the surging
interest for their potential to cure human genetic diseases by gene transfer, tumbled on low …

Recombinant adeno-associated virus (rAAV) is a widely used viral vector for gene therapy.
Despite its clinical efficacy, the manufacturing of rAAV faces challenges in productivity and …