Understanding inbreeding depression, purging, and genetic rescue

PW Hedrick, A Garcia-Dorado - Trends in ecology & evolution, 2016 - cell.com
Inbreeding depression, the reduction of fitness caused by inbreeding, is a nearly universal
phenomenon that depends on past mutation, selection, and genetic drift. Recent estimates …

Inbreeding depression due to recent and ancient inbreeding in Dutch Holstein–Friesian dairy cattle

HP Doekes, RF Veerkamp, P Bijma, G de Jong… - Genetics Selection …, 2019 - Springer
Background Inbreeding decreases animal performance (inbreeding depression), but not all
inbreeding is expected to be equally harmful. Recent inbreeding is expected to be more …

Nonequivalent lethal equivalents: Models and inbreeding metrics for unbiased estimation of inbreeding load

P Nietlisbach, S Muff, JM Reid… - Evolutionary …, 2019 - Wiley Online Library
Inbreeding depression, the deterioration in mean trait value in progeny of related parents, is
a fundamental quantity in genetics, evolutionary biology, animal and plant breeding, and …

Characterizing and Eliminating the Inbreeding Load

I Nagy, TA Nguyen - Veterinary Sciences, 2023 - mdpi.com
Simple Summary Inbreeding, which is the mating of related animals, is a general
phenomenon in closed populations. Because it is often associated with a decrease in …

Long-term exhaustion of the inbreeding load in Drosophila melanogaster

N Pérez-Pereira, R Pouso, A Rus, A Vilas… - Heredity, 2021 - nature.com
Inbreeding depression, the decline in fitness of inbred individuals, is a ubiquitous
phenomenon of great relevance in evolutionary biology and in the fields of animal and plant …

Revised calculation of Kalinowski's ancestral and new inbreeding coefficients

HP Doekes, I Curik, I Nagy, J Farkas, G Kövér… - Diversity, 2020 - mdpi.com
To test for the presence of purging in populations, the classical pedigree-based inbreeding
coefficient (F) can be decomposed into Kalinowski's ancestral (FANC) and new (FNEW) …

Prediction of fitness under different breeding designs in conservation programs

N Pérez‐Pereira, E López‐Cortegano… - Animal …, 2023 - Wiley Online Library
The expected change in fitness under inbreeding due to deleterious recessive alleles
depends on the amount of inbreeding load harbored by a population, that is, the load of …

Inbreeding load and inbreeding depression estimated from lifetime reproductive success in a small, dispersal-limited population

JR Willoughby, PM Waser, A Brüniche-Olsen… - Heredity, 2019 - nature.com
The fitness consequences of inbreeding and the individual behaviors that prevent its
detrimental effects can be challenging to document in wild populations. Here, we use field …

Genetic purging in captive endangered ungulates with extremely low effective population sizes

E López-Cortegano, E Moreno, A García-Dorado - Heredity, 2021 - nature.com
Inbreeding threatens the survival of small populations by producing inbreeding depression,
but also exposes recessive deleterious effects in homozygosis allowing for genetic purging …

purgeR: inbreeding and purging in pedigreed populations

E López-Cortegano - Bioinformatics, 2022 - academic.oup.com
Inbreeding depression and genetic purging are important processes shaping the
survivability and evolution of small populations. However, detecting purging is challenging …