A guide to cell death pathways

J Yuan, D Ofengeim - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Regulated cell death mediated by dedicated molecular machines, known as programmed
cell death, plays important roles in health and disease. Apoptosis, necroptosis and …

Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

High-speed fluorescence image–enabled cell sorting

D Schraivogel, TM Kuhn, B Rauscher… - Science, 2022 - science.org
Fast and selective isolation of single cells with unique spatial and morphological traits
remains a technical challenge. Here, we address this by establishing high-speed image …

NF‐κB signaling in inflammation and cancer

T Zhang, C Ma, Z Zhang, H Zhang, H Hu - MedComm, 2021 - Wiley Online Library
Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …

A targetable LIFR− NF-κB− LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis

F Yao, Y Deng, Y Zhao, Y Mei, Y Zhang, X Liu… - Nature …, 2021 - nature.com
The growing knowledge of ferroptosis has suggested the role and therapeutic potential of
ferroptosis in cancer, but has not been translated into effective therapy. Liver cancer …

Toll-like receptors and the control of immunity

KA Fitzgerald, JC Kagan - Cell, 2020 - cell.com
The study of innate immunity and its link to inflammation and host defense encompasses
diverse areas of biology, ranging from genetics and biophysics to signal transduction and …

The role of ubiquitination in tumorigenesis and targeted drug discovery

L Deng, T Meng, L Chen, W Wei, P Wang - Signal transduction and …, 2020 - nature.com
Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

[HTML][HTML] The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseases

MR Zinatizadeh, B Schock, GM Chalbatani, PK Zarandi… - Genes & diseases, 2021 - Elsevier
The nuclear factor kappa B (NF-êB) family of transcription factors plays an essential role as
stressors in the cellular environment, and controls the expression of important regulatory …

The cytokine network involved in the host immune response to periodontitis

W Pan, Q Wang, Q Chen - International journal of oral science, 2019 - nature.com
Periodontitis is an inflammatory disease involving the destruction of both soft and hard tissue
in the periodontal region. Although dysbiosis of the local microbial community initiates local …

Ubiquitination in the regulation of inflammatory cell death and cancer

PE Cockram, M Kist, S Prakash, SH Chen… - Cell Death & …, 2021 - nature.com
The ubiquitin system is complex, multifaceted, and is crucial for the modulation of a vast
number of cellular processes. Ubiquitination is tightly regulated at different levels by a range …