Hydrogels are crosslinked polymer chains with three-dimensional (3D) network structures,
which can absorb relatively large amounts of fluid. Because of the high water content, soft …

In recent years, a range of studies have been conducted with the aim to design and
characterize delivery systems that are able to release multiple therapeutic agents in …

Hyaluronan (HA) is a critical element of the extracellular matrix (ECM). The regulated
synthesis and degradation of HA modulates the ECM chemical and physical properties that …

Extracellular matrix is a complex network of macromolecules that constitute a
microenvironment of normal tissues and malignancies such as the primary brain tumor …

Glioblastoma (GBM) is the most prevalent and lethal adult primary central nervous system
cancer. An immunosuppresive and highly heterogeneous tumor microenvironment …

The process of evaluating the efficacy and toxicity of drugs is important in the production of
new drugs to treat diseases. Testing in humans is the most accurate method, but there are …

Gliomas are a diverse group of primary central nervous system tumors that affect both
children and adults. Recent studies have revealed a dynamic cross talk that occurs between …

Glioblastoma (GBM) is the most aggressive and common form of primary brain cancer.
Several decades of research have provided great insight into GBM progression; however …

The lack of in vitro models that represent the native tumor microenvironment is a significant
challenge for cancer research. Two-dimensional (2D) monolayer culture has long been the …

Glioblastoma multiforme (GBM) is the most lethal primary brain tumor characterized by high
cellular and molecular heterogeneity, hypervascularization, and innate drug resistance …