Colorectal cancer (CRC) is a prevalent disease worldwide, with more than 50% of patients
developing metastases to the liver. Five-year overall survival remains modest among …

The clinical, histological, and molecular differences between right-sided colon cancer (RCC)
and left-sided colon cancer (RCC) have received considerable attention. Over the past …

Background ALKBH5 belongs to the ALKB family consists of a Fe (II) and a-ketoglutarate-
dependent dioxygenase. ALKBH5 directly catalyzes the oxidative demethylation of m6A …

Abstract Introduction Several parts of Garcinia hanburyi are used in traditional medicine for
many purposes. In this study, Garcinia hanburyi resin (GHR) was explored for possible anti …

Colorectal cancer (CRC) is one of the most frequently occurring tumors. Ferula assa-foetida
oleo-gum–resin (OGR) extract is a traditional cooking spice known for its broad spectrum of …

Colorectal liver metastasis (CRLM) is challenging in the clinical treatment of colorectal
cancer. Limited research has been conducted on how CRLM develops. RNA sequencing …

Colorectal cancer (CRC) is a serious public health problem known to have a multifactorial
etiology. The association between gut microbiota and CRC has been widely studied; …

Immune checkpoint inhibitors (ICIs) have achieved remarkable success in clinical research
and practice. Notably, liver metastasis is not sensitive to ICIs. Liver locoregional therapies …

Background Liver transplantation (LT) is considered a therapeutic option for unresectable
perihilar cholangiocarcinoma (PHC) within defined criteria. It remains uncertain whether …

Resistance to chimeric antigen receptor (CAR) T-cell therapy remains a significant
challenge in the treatment of solid tumors. This resistance is attributed to various factors …