Relaxin family peptides and their receptors

RAD Bathgate, ML Halls… - Physiological …, 2013 - journals.physiology.org
There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has
many roles in female and male reproduction, as a neuropeptide in the central nervous …

Relaxin's physiological roles and other diverse actions

OD Sherwood - Endocrine reviews, 2004 - academic.oup.com
Relaxin has vital physiological roles in pregnant rats, mice, and pigs. Relaxin promotes
growth and softening of the cervix, thus facilitating rapid delivery of live young. Relaxin also …

Anti‐Inflammatory Activities of Cinnamomum cassia Constituents In Vitro and In Vivo

JC Liao, JS Deng, CS Chiu, WC Hou… - Evidence‐Based …, 2012 - Wiley Online Library
We have investigated the anti‐inflammatory effects of Cinnamomum cassia constituents
(cinnamic aldehyde, cinnamic alcohol, cinnamic acid, and coumarin) using …

The effect of relaxin on the musculoskeletal system

F Dehghan, BS Haerian, S Muniandy… - … journal of medicine …, 2014 - Wiley Online Library
Relaxin is a hormone structurally related to insulin and insulin‐like growth factor, which
exerts its regulatory effect on the musculoskeletal and other systems through binding to its …

Adipokines and inflammation: focus on cardiovascular diseases

S Feijóo-Bandín, A Aragón-Herrera… - International journal of …, 2020 - mdpi.com
It is well established that adipose tissue, apart from its energy storage function, acts as an
endocrine organ that produces and secretes a number of bioactive substances, including …

Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes

YC Shen, WF Chiou, YC Chou, CF Chen - European journal of …, 2003 - Elsevier
To evaluate the possible mechanisms responsible for the anti-inflammatory effects of
baicalin or baicalein, phorbol-12-myristate-13-acetate (PMA)-or N-formyl-methionyl-leucyl …

International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family …

ML Halls, RAD Bathgate, SW Sutton… - Pharmacological …, 2015 - Elsevier
Abstract Relaxin, insulin-like peptide 3 (INSL3), relaxin-3, and INSL5 are the cognate
ligands for the relaxin family peptide (RXFP) receptors 1–4, respectively. RXFP1 activates …

Cardiovascular effects of relaxin: from basic science to clinical therapy

XJ Du, RAD Bathgate, CS Samuel, AM Dart… - Nature Reviews …, 2010 - nature.com
Although substantial advances have been achieved in recent decades in the clinical
management of heart diseases, new therapies that provide better or additional efficacy with …

The anti-inflammatory effect of honokiol on neutrophils: mechanisms in the inhibition of reactive oxygen species production

KT Liou, YC Shen, CF Chen, CM Tsao… - European journal of …, 2003 - Elsevier
Reactive oxygen species produced by neutrophils contribute to the pathogenesis of focal
cerebral ischemia/reperfusion injury and signal the inflammatory response. We have …

Reperfusion therapy with recombinant human relaxin-2 (Serelaxin) attenuates myocardial infarct size and NLRP3 inflammasome following ischemia/reperfusion injury …

J Valle Raleigh, AG Mauro… - Cardiovascular …, 2017 - academic.oup.com
Aims The preconditioning-like infarct-sparing and anti-inflammatory effects of the peptide
hormone relaxin following ischemic injury have been studied in the heart. Whether …