T cell antigen receptor recognition of antigen-presenting molecules
The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
Gapped sequence alignment using artificial neural networks: application to the MHC class I system
M Andreatta, M Nielsen - Bioinformatics, 2016 - academic.oup.com
Motivation: Many biological processes are guided by receptor interactions with linear
ligands of variable length. One such receptor is the MHC class I molecule. The length …
ligands of variable length. One such receptor is the MHC class I molecule. The length …
A structural voyage toward an understanding of the MHC‐I‐restricted immune response: lessons learned and much to be learned
T cells that express clonally distributed αβ T‐cell receptors (TCR s) corecognize antigenic
peptides (p) bound to major histocompatibility complex class I (MHC‐I) and class II …
peptides (p) bound to major histocompatibility complex class I (MHC‐I) and class II …
Structural dissimilarity from self drives neoepitope escape from immune tolerance
JR Devlin, JA Alonso, CM Ayres, GLJ Keller… - Nature chemical …, 2020 - nature.com
T-cell recognition of peptides incorporating nonsynonymous mutations, or neoepitopes, is a
cornerstone of tumor immunity and forms the basis of new immunotherapy approaches …
cornerstone of tumor immunity and forms the basis of new immunotherapy approaches …
Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities
The absence of preexisting neutralizing antibodies specific for the novel A (H7N9) influenza
virus indicates a lack of prior human exposure. As influenza A virus–specific CD8+ T …
virus indicates a lack of prior human exposure. As influenza A virus–specific CD8+ T …
[PDF][PDF] A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells
K Ladell, M Hashimoto, MC Iglesias, PG Wilmann… - Immunity, 2013 - cell.com
The capacity of the immune system to adapt to rapidly evolving viruses is a primary feature
of effective immunity, yet its molecular basis is unclear. Here, we investigated protective HIV …
of effective immunity, yet its molecular basis is unclear. Here, we investigated protective HIV …
High-functional-avidity cytotoxic T lymphocyte responses to HLA-B-restricted Gag-derived epitopes associated with relative HIV control
Virus-specific cytotoxic T lymphocytes (CTL) with high levels of functional avidity have been
associated with viral clearance in hepatitis C virus infection and with enhanced antiviral …
associated with viral clearance in hepatitis C virus infection and with enhanced antiviral …
[HTML][HTML] Naturally processed non-canonical HLA-A* 02: 01 presented peptides
C Hassan, E Chabrol, L Jahn, MGD Kester… - Journal of Biological …, 2015 - ASBMB
Human leukocyte antigen (HLA) class I molecules generally present peptides (p) of 8 to 11
amino acids (aa) in length. Although an increasing number of examples with lengthy (> 11 …
amino acids (aa) in length. Although an increasing number of examples with lengthy (> 11 …
Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1
ABSTRACT HLA class I-associated polymorphisms identified at the population level mark
viral sites under immune pressure by individual HLA alleles. As such, analysis of their …
viral sites under immune pressure by individual HLA alleles. As such, analysis of their …
[HTML][HTML] Antigenic peptide prediction from E6 and E7 oncoproteins of HPV types 16 and 18 for therapeutic vaccine design using immunoinformatics and MD simulation …
Human papillomavirus (HPV) induced cervical cancer is the second most common cause of
death, after breast cancer, in females. Three prophylactic vaccines by Merck Sharp & Dohme …
death, after breast cancer, in females. Three prophylactic vaccines by Merck Sharp & Dohme …