Background Nature has provided unique molecular scaffolds for applications including
therapeutics, agriculture, and food. Due to differences in ecological environments and …

Elucidating the mechanism of action (MoA) of antibacterial natural products is crucial to
evaluating their potential as novel antibiotics. Marinopyrroles, pentachloropseudilin, and …

The natural product armeniaspirol possesses a unique spirocyclic N, O-ketal in an α, β-
dichloro-α, β-unsaturated lactam scaffold that has proved challenging to synthesize. Herein …

The armeniaspirol family of natural product antibiotics have been shown to inhibit the ATP-
dependent proteases ClpXP and ClpYQ and disrupt membrane potential through shuttling of …

In the search for antibacterial compounds that can overcome drug resistant species,
molecules that enact novel or polypharmacological mechanisms of action (MoA) are …

In the fight against bacterial infections, particularly those caused by multi‐resistant
pathogens, the need for new antibacterials is undoubted in scientific communities. and is by …

Abstract In the Hudson Lab, which is focused on discovering new antibiotics, bacteria
samples are taken from the environment and cultured in large quantities. Then they are …

La chimie des hétérocycles est un élément central des sciences chimiques qui contribue
fortement à la conception de médicaments ainsi qu'à de nouveaux matériaux de propriétés …

Antimicrobial resistance is a human health issue that demands development of new
antibiotics with unique mechanisms of action to combat antibiotic failure in the clinic …

Antimicrobial resistance poses a serious threat to public health, causing numerous deaths
annually. Natural products offer potential for new antimicrobial therapies amidst bacterial …