Cartilage injuries are typically caused by trauma, chronic overload, and autoimmune
diseases. Owing to the avascular structure and low metabolic activities of chondrocytes …

Articular cartilage is a load‐bearing tissue playing a crucial mechanical role in diarthrodial
joints, facilitating joint articulation, and minimizing wear. The significance of biomechanical …

Organ-on-chip (OOC) systems recapitulate key biological processes and responses in vitro
exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and …

Biophysical cues play a key role in directing the lineage commitment of mesenchymal stem
cells or multipotent stromal cells (MSC s), but the mechanotransductive mechanisms at play …

The use of cell-rich hydrogels for three-dimensional (3D) cell culture has shown great
potential for a variety of biomedical applications. However, the fabrication of appropriate …

Osteoarthritis is a degenerative joint disease characterized by pain and disability. It involves
all ages and 70% of people aged> 65 have some degree of osteoarthritis. Natural cartilage …

Articular cartilage is a highly specialized tissue whose remarkable properties of
deformability, resistance to mechanical loading, and low-friction gliding are essential to joint …

Human mesenchymal stem cells (MSCs) reside under hypoxic conditions in vivo, between
4% and 7% oxygen. Differentiation of MSCs under hypoxic conditions results in inhibited …

Background Worldwide, many people suffer from knee injuries and articular cartilage
damage every year, which causes pain and reduces productivity, life quality, and daily …

There is great interest in how bone marrow derived stem cells make fate decisions.
Numerous studies have investigated the role of individual growth factors on mesenchymal …