[HTML][HTML] Anticancer therapeutic potential of benzofuran scaffolds
Benzofuran moiety is the main component of many biologically active natural and synthetic
heterocycles. These heterocycles have unique therapeutic potentials and are involved in …
heterocycles. These heterocycles have unique therapeutic potentials and are involved in …
Design and synthesis of benzothiazole-based SLC-0111 analogues as new inhibitors for the cancer-associated carbonic anhydrase isoforms IX and XII
In this work, different series of benzothiazole-based sulphonamides 8a-c, 10, 12, 16a-b and
carboxylic acids 14a-c were developed as novel SLC-0111 analogues with the goal of …
carboxylic acids 14a-c were developed as novel SLC-0111 analogues with the goal of …
Discovery of sulfonamide-tethered isatin derivatives as novel anticancer agents and VEGFR-2 inhibitors
In this work, new isatin-based sulphonamides (6a-i, 11a-c, 12a-c) were designed and
synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer …
synthesised as potential dual VEGFR-2 and carbonic anhydrase inhibitors with anticancer …
Furan and benzofuran derivatives as privileged scaffolds as anticancer agents: SAR and docking studies (2010 to till date)
Furan and benzofuran scaffolds are privileged and well-studied heterocyclic rings for
designing and developing new potential anticancer compounds. Previous literature showed …
designing and developing new potential anticancer compounds. Previous literature showed …
[HTML][HTML] Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens
Microbial Multidrug Resistance (MDR) is an emerging global crisis. Derivatization of natural
or synthetic scaffolds is among the most reliable strategies to search for and obtain novel …
or synthetic scaffolds is among the most reliable strategies to search for and obtain novel …
One-pot three-component synthesis of novel pyrazolo [3, 4-b] pyridines as potent antileukemic agents
RF Barghash, WM Eldehna, M Kovalova… - European Journal of …, 2022 - Elsevier
In the current study, we report on the development of novel series of pyrazolo [3, 4-b]
pyridine derivatives (8a-u, 11a-n, and 14a, b) as potential anticancer agents. The prepared …
pyridine derivatives (8a-u, 11a-n, and 14a, b) as potential anticancer agents. The prepared …
Novel 3-(6-methylpyridin-2-yl) coumarin-based chalcones as selective inhibitors of cancer-related carbonic anhydrases IX and XII endowed with anti-proliferative …
Carbonic anhydrases (CAs) are one of the promising targets for the development of
anticancer agents. CA isoforms are implicated in various physiological processes and are …
anticancer agents. CA isoforms are implicated in various physiological processes and are …
[HTML][HTML] 1-Benzyl-5-bromo-3-hydrazonoindolin-2-ones as novel anticancer agents: Synthesis, biological evaluation and molecular modeling insights
Human health is experiencing several obstacles in the modern medical era, particularly
cancer. As a result, the cancer therapeutic arsenal should be continually expanded with …
cancer. As a result, the cancer therapeutic arsenal should be continually expanded with …
Phthalimide‐tethered isatins as novel poly (ADP‐ribose) polymerase inhibitors: Design, synthesis, biological evaluations, and molecular modeling investigations
Humanity is currently facing various diseases with significant mortality rates, particularly
those associated with malignancies. Numerous enzymes and proteins have been identified …
those associated with malignancies. Numerous enzymes and proteins have been identified …
Development of novel anilinoquinazoline-based carboxylic acids as non-classical carbonic anhydrase IX and XII inhibitors
As part of our ongoing endeavour to identify novel inhibitors of cancer-associated CA
isoforms IX and XII as possible anticancer candidates, here we describe the design and …
isoforms IX and XII as possible anticancer candidates, here we describe the design and …