Developing neurons connect in specific and stereotyped ways to form the complex circuits
that underlie brain function. By comparison to earlier steps in neural development, progress …

A dramatic maturational process ongoing in adolescence is prefrontal cortex development,
including its dopamine innervation. Dopamine axons grow from the striatum to the prefrontal …

Probing how human neural networks operate is hindered by the lack of reliable human
neural tissues amenable to the dynamic functional assessment of neural circuits. We …

Backgroud Variations in the expression of the Netrin-1 guidance cue receptor DCC (deleted
in colorectal cancer) appear to confer resilience or susceptibility to psychopathologies …

The numbers and strengths of synapses in the brain change throughout development, and
even into adulthood, as synaptic inputs are added, eliminated, and refined in response to …

The molecular code that controls synapse formation and maintenance in vivo has remained
quite sparse. Here, we identify that the secreted protein Adamtsl3 functions as critical …

Axons need to be properly guided to their targets to form synaptic connections, and this
requires interactions between highly conserved extracellular and transmembrane ligands …

Evidence is emerging that immune responses not only play a part in the central nervous
system (CNS) in diseases but may also be relevant for healthy conditions. We discovered a …

Neurotrophic factors are essential not only for guiding the organization of the developing
nervous system but also for supporting the survival and growth of neurons after traumatic …

The development of a functional nervous system entails establishing connectivity between
appropriate synaptic partners. During axonal pathfinding, the developing axon navigates …