Malaria: biology and disease

AF Cowman, J Healer, D Marapana, K Marsh - Cell, 2016 - cell.com
Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …

Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria

JG Beeson, DR Drew, MJ Boyle, G Feng… - FEMS microbiology …, 2016 - academic.oup.com
Malaria accounts for an enormous burden of disease globally, with Plasmodium falciparum
accounting for the majority of malaria, and P. vivax being a second important cause …

[HTML][HTML] Malaria diagnosis: a brief review

N Tangpukdee, C Duangdee… - The Korean journal of …, 2009 - ncbi.nlm.nih.gov
Malaria is a major cause of death in tropical and sub-tropical countries, killing each year
over 1 million people globally; 90% of fatalities occur in African children. Although effective …

Reverse vaccinology: developing vaccines in the era of genomics

A Sette, R Rappuoli - Immunity, 2010 - cell.com
The sequence of microbial genomes made all potential antigens of each pathogen available
for vaccine development. This increased by orders of magnitude potential vaccine targets in …

A prospective analysis of the Ab response to Plasmodium falciparum before and after a malaria season by protein microarray

PD Crompton, MA Kayala, B Traore… - Proceedings of the …, 2010 - National Acad Sciences
Abs are central to malaria immunity, which is only acquired after years of exposure to
Plasmodium falciparum (Pf). Despite the enormous worldwide burden of malaria, the targets …

Novel serologic biomarkers provide accurate estimates of recent Plasmodium falciparum exposure for individuals and communities

DA Helb, KKA Tetteh, PL Felgner… - Proceedings of the …, 2015 - National Acad Sciences
Tools to reliably measure Plasmodium falciparum (Pf) exposure in individuals and
communities are needed to guide and evaluate malaria control interventions. Serologic …

Advances and challenges in malaria vaccine development

PD Crompton, SK Pierce… - The Journal of clinical …, 2010 - Am Soc Clin Investig
Malaria caused by Plasmodium falciparum remains a major public health threat, especially
among children and pregnant women in Africa. An effective malaria vaccine would be a …

Overview of protein microarrays

FXR Sutandy, J Qian, CS Chen… - Current protocols in …, 2013 - Wiley Online Library
Protein microarray technology is an emerging field that provides a versatile platform for the
characterization of hundreds of thousands of proteins in a highly parallel and high …

New antigens for a multicomponent blood-stage malaria vaccine

FH Osier, MJ Mackinnon, C Crosnier, G Fegan… - Science translational …, 2014 - science.org
An effective blood-stage vaccine against Plasmodium falciparum remains a research
priority, but the number of antigens that have been translated into multicomponent vaccines …

Genetic diversity and malaria vaccine design, testing and efficacy: preventing and overcoming 'vaccine resistant malaria'

SL Takala, CV Plowe - Parasite immunology, 2009 - Wiley Online Library
The development of effective malaria vaccines may be hindered by extensive genetic
diversity in the surface proteins being employed as vaccine antigens. Understanding of the …