Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …

Polycomb (PcG) and Trithorax (TrxG) group proteins are evolutionarily conserved chromatin-
modifying factors originally identified as part of an epigenetic cellular memory system that …

The stalling of ribosomes during protein synthesis results in the production of truncated
polypeptides that can have deleterious effects on cells and therefore must be eliminated. In …

Ubiquitin E3 ligases control every aspect of eukaryotic biology by promoting protein
ubiquitination and degradation. At the end of a three-enzyme cascade, ubiquitin ligases …

Since the first high-resolution structure of the nucleosome was reported in 1997, the
available information on chromatin structure has increased very rapidly. Here, we review …

The BRCA1–BARD1 tumour suppressor is an E3 ubiquitin ligase necessary for the repair of
DNA double-strand breaks by homologous recombination,,,,,,,,–. The BRCA1–BARD1 …

In response to growth signals, mechanistic target of rapamycin complex 1 (mTORC1)
stimulates anabolic processes underlying cell growth. We found that mTORC1 increases …

Covalent attachment (conjugation) of one or more ubiquitin molecules to protein substrates
governs numerous eukaryotic cellular processes, including apoptosis, cell division and …

The heavily used protein–protein docking server ClusPro performs three computational
steps as follows:(1) rigid body docking,(2) RMSD based clustering of the 1000 lowest energy …

Ubiquitin-like proteins (Ubl's) are conjugated to target proteins or lipids to regulate their
activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin …