Whether the human fetus and the prenatal intrauterine environment (amniotic fluid and
placenta) are stably colonized by microbial communities in a healthy pregnancy remains a …

The interplay between the commensal microbiota and the mammalian immune system
development and function includes multifold interactions in homeostasis and disease. The …

Bacteria were first detected in human tumors more than 100 years ago, but the
characterization of the tumor microbiome has remained challenging because of its low …

From early life to adulthood, the microbiota play a crucial role in the health of the infant. The
microbiota in early life are not only a key regulator of infant health but also associated with …

Uncovering mechanisms underlying fetal programming during pregnancy is of critical
importance. Atypical neurodevelopment during the pre-and immediate postnatal period has …

The innate immune system is the oldest protection strategy that is conserved across all
organisms. Although having an unspecific action, it is the first and fastest defense …

The microbiome has been proven to be associated with many diseases and has been used
as a biomarker and target in disease prevention and intervention. Currently, the vital role of …

Highlights•In utero microbial stimulation modulates both prenatal and postnatal immune cell
development.•Unique neonatal gut microenvironment allows for progressive colonization of …

At birth, neonates provide a vast habitat awaiting microbial colonization. Microbiome
assembly is a complex process involving microbial seeding and succession driven by …

Pregnant women represent a high-risk population for severe/critical COVID-19 and mortality.
However, the maternal-fetal immune responses initiated by SARS-CoV-2 infection, and …