Synaptic dysfunction in ALS and FTD: anatomical and molecular changes provide insights into mechanisms of disease
PA Gelon, PA Dutchak, CF Sephton - Frontiers in Molecular …, 2022 - frontiersin.org
Synaptic loss is a pathological feature of all neurodegenerative diseases including
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ALS is a disease of …
amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). ALS is a disease of …
Deficient neurotransmitter systems and synaptic function in frontotemporal lobar degeneration—Insights into disease mechanisms and current therapeutic approaches
N Huber, S Korhonen, D Hoffmann, S Leskelä… - Molecular …, 2022 - nature.com
Frontotemporal lobar degeneration (FTLD) comprises a heterogenous group of fatal
neurodegenerative diseases and, to date, no validated diagnostic or prognostic biomarkers …
neurodegenerative diseases and, to date, no validated diagnostic or prognostic biomarkers …
SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS
GR Linares, Y Li, WH Chang, J Rubin-Sigler… - Cell Stem Cell, 2023 - cell.com
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by many
diverse genetic etiologies. Although therapeutics that specifically target causal mutations …
diverse genetic etiologies. Although therapeutics that specifically target causal mutations …
An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD
CS Bauer, RN Cohen, F Sironi, MR Livesey… - Acta …, 2022 - Springer
Dysfunction and degeneration of synapses is a common feature of amyotrophic lateral
sclerosis and frontotemporal dementia (ALS/FTD). A GGGGCC hexanucleotide repeat …
sclerosis and frontotemporal dementia (ALS/FTD). A GGGGCC hexanucleotide repeat …
Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortex
Increasing evidence suggests synaptic dysfunction is a central and possibly triggering factor
in Amyotrophic Lateral Sclerosis (ALS). Despite this, we still know very little about the …
in Amyotrophic Lateral Sclerosis (ALS). Despite this, we still know very little about the …
Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregation
F Liu, D Morderer, MC Wren… - Acta Neuropathologica …, 2022 - Springer
The most common inherited cause of two genetically and clinico-pathologically overlapping
neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal …
neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal …
Emerging perspectives on dipeptide repeat proteins in C9ORF72 ALS/FTD
A Schmitz, J Pinheiro Marques, I Oertig… - Frontiers in cellular …, 2021 - frontiersin.org
The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal
dementia (FTD) is a hexanucleotide expansion in the chromosome 9 open reading frame 72 …
dementia (FTD) is a hexanucleotide expansion in the chromosome 9 open reading frame 72 …
Stimulating VAPB-PTPIP51 ER-mitochondria tethering corrects FTD/ALS mutant TDP43 linked Ca2+ and synaptic defects
A Markovinovic, SM Martín-Guerrero… - Acta Neuropathologica …, 2024 - Springer
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are clinically linked
major neurodegenerative diseases. Notably, TAR DNA-binding protein-43 (TDP43) …
major neurodegenerative diseases. Notably, TAR DNA-binding protein-43 (TDP43) …
Reduced C9orf72 function leads to defective synaptic vesicle release and neuromuscular dysfunction in zebrafish
Z Butti, YE Pan, J Giacomotto, SA Patten - Communications biology, 2021 - nature.com
The most common genetic cause of amyotrophic lateral sclerosis (ALS) and fronto-temporal
dementia (FTD) is a hexanucleotide repeat expansion within the C9orf72 gene. Reduced …
dementia (FTD) is a hexanucleotide repeat expansion within the C9orf72 gene. Reduced …
Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS
A Aly, ZI Laszlo, S Rajkumar, T Demir, N Hindley… - Acta …, 2023 - Springer
Abstract Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease mainly
affecting upper and lower motoneurons. Several functionally heterogeneous genes have …
affecting upper and lower motoneurons. Several functionally heterogeneous genes have …