Synthesis of biologically active molecules through multicomponent reactions

D Insuasty, J Castillo, D Becerra, H Rojas, R Abonia - Molecules, 2020 - mdpi.com
Focusing on the literature progress since 2002, the present review explores the highly
significant role that multicomponent reactions (MCRs) have played as a very important tool …

Silver-catalyzed synthesis of nitrogen heterocycles: recent advancements

PS Devi, M Neetha, G Anilkumar - Organic & Biomolecular Chemistry, 2023 - pubs.rsc.org
Heterocyclic chemistry is an ever-expanding field without boundaries. Heterocycles play a
significant role in medicinal and pharmaceutical chemistry, the agricultural industry and …

Fine particulate matter leads to reproductive impairment in male rats by overexpressing phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway

X Cao, C Yan, D Liu, J Peng, J Chen, Y Zhou, C Long… - Toxicology letters, 2015 - Elsevier
Maintenance of male reproductive function depends on normal sperm generation during
which process Sertoli cells play a vital role. Studies found that fine particulate matter (PM) …

Innovative Approaches to Alzheimer's Therapy: Harnessing the Power of Heterocycles, Oxidative Stress Management, and Nanomaterial Drug Delivery System

M Umar, Y Rehman, S Ambreen, SM Mumtaz… - Ageing Research …, 2024 - Elsevier
Alzheimer's disease (AD) presents a complex pathology involving amyloidogenic
proteolysis, neuroinflammation, mitochondrial dysfunction, and cholinergic deficits. Oxidative …

Antioxidant capacity of simplified oxygen heterocycles and proposed derivatives by theoretical calculations

RS Borges, CPO Aguiar, NLL Oliveira… - Journal of Molecular …, 2023 - Springer
Context Some structural properties can be involved in the antioxidant capacity of several
polyphenol derivatives, among them their simplified structures. This study examines the …

Antioxidant serine-(NSAID) hybrids with anti-inflammatory and hypolipidemic potency

P Theodosis-Nobelos, G Papagiouvannis, P Tziona… - Molecules, 2021 - mdpi.com
A series of L-serine amides of antioxidant acids, such as Trolox,(E)-3-(3, 5-di-tert-butyl-4-
hydroxyphenyl) acrylic acid (phenolic derivative of cinnamic acid) and 3, 5-di-tert-butyl-4 …

Development in the Synthesis of Bioactive Thiazole-Based Heterocyclic Hybrids Utilizing Phenacyl Bromide

G Kumari, S Dhillon, P Rani, M Chahal, DK Aneja… - ACS …, 2024 - ACS Publications
Heterocyclic hybrid frameworks represent a burgeoning domain within the realms of drug
discovery and medicinal chemistry, attracting considerable attention in recent years …

Synthesis and electrochemical and antioxidant properties of chalcogenocyanate oxadiazole and 5-heteroarylchalcogenomethyl-1 H-tetrazole derivatives

JG Leal, AC Sauer, JCP Mayer, ST Stefanello… - New Journal of …, 2017 - pubs.rsc.org
This article presents the chalcogenocyanate oxadiazoles 7 and 8 and their derivatives 5-
heteroarylchalcogenomethyl-1H-tetrazoles 9 and 10, which were synthesized in high yields …

Microwave Induced Green Chemistry Approach Towards the Synthesis of Heterocyclic Compounds via CN Bond Forming Reactions

BK Banik, BM Sahoo, BVV Kumar… - Current Microwave …, 2021 - ingentaconnect.com
The synthesis of heterocyclic compounds via carbon-nitrogen (CN) bond formation reaction
is considered an emerging and efficient protocol in the field of synthetic chemistry. The C–N …

Antioxidant and antimicrobial activities of some novel 2-thiohydantoin derivatives

DZ Mutlaq, AAA Al-Shawi… - Egyptian Journal of …, 2021 - ejchem.journals.ekb.eg
Four new 2-thiohydantoin derivatives (4a-d) were synthesized from the reaction of
maleimide derivatives (3a-d) with phenylisothiocyanate. The structures of synthetic …