This article reviews the discovery of PCSK9, its structure–function characteristics, and its
presently known and proposed novel biological functions. The major critical function of …

Obesity, a pandemic of the modern world, is intimately associated with dyslipidemia, which
is mainly driven by the effects of insulin resistance and pro-inflammatory adipokines …

Cardiovascular disease remains the principal cause of death and disability among patients
with diabetes mellitus. Diabetes mellitus exacerbates mechanisms underlying …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has evolved as a pivotal enzyme in
lipid metabolism and a revolutionary therapeutic target for hypercholesterolemia and its …

Hepatocellular carcinoma (HCC) is an increasing burden on global public health and is
associated with enhanced lipogenesis, fatty acid uptake, and lipid metabolic …

Unknown 15 years ago, PCSK9 (proprotein convertase subtilisin/kexin type 9) is now
common parlance among scientists and clinicians interested in prevention and treatment of …

Since the discovery of proprotein convertase subtilisin kexin 9 (PCSK9) in 2003, this PC has
attracted a lot of attention from the scientific community and pharmaceutical companies …

AMPK has emerged as a critical mechanism for salutary effects of polyphenols on lipid
metabolic disorders in type 1 and type 2 diabetes. Here we demonstrate that AMPK interacts …

Background A low plasma level of low-density lipoprotein (LDL) cholesterol is associated
with reduced risk of coronary heart disease (CHD), but the effect of lifelong reductions in …

PCSK9 proprotein convertase subtilisin/kexin type (PCSK9) is a crucial protein in LDL
cholesterol (LDL-C) metabolism by virtue of its pivotal role in the degradation of the LDL …