Following the success of mRNA vaccines against COVID-19, mRNA-based therapeutics
have now become a great interest and potential. The development of this approach has …

Eukaryotic translation initiation factor 4E (eIF4E) is an RNA-binding protein that binds to the
m7GpppX-cap at the 5′ terminus of coding mRNAs to initiate cap-dependent translation …

Aryloxy triester phosphoramidate methodology, commonly known as ProTide technology, is
one of the most widely used prodrug approaches applied to therapeutic nucleosides. This …

Fluorescence anisotropy (FA) is a powerful technique for the discovery of protein inhibitors
in a high-throughput manner. In this study, we sought to develop new universal FA-based …

In the fight against cancer, researchers have turned their attention to the eukaryotic initiation
factor eIF4E, a protein whose increased level is strongly correlated with the development …

Microbiome Metabolic Pathways and Disease provides insight into the interaction of
microbial metabolic pathways in the human body and the impact these can have on a variety …

ADP-ribosylation is a key protein modification involved in cell signaling pathways, where
ADP-ribose units are incorporated into the macromolecules by PARP enzymes, using NAD+ …

A convenient feasible protocol was developed for the preparation of novel tryptamine
derivatives from evodiamine. After the general alkylation in N-13 and followed by the …

Informacyjny RNA (mRNA, ang. messenger RNA) rezprezentuje kopię informacji
genetycznej, przepisywanej w procesie transkrypcji z DNA w postaci komplementarnej …