Despite significant progress in antibiotic discovery, millions of lives are lost annually to
infections. Surprisingly, the failure of antimicrobial treatments to effectively eliminate …

Intra-abdominal infections (IAI) are among the most common global healthcare challenges
and they are usually precipitated by disruption to the gastrointestinal (GI) tract. Their …

Purpose Individualising drug dosing using model-informed precision dosing (MIPD) of beta-
lactam antibiotics and ciprofloxacin has been proposed as an alternative to standard dosing …

Purpose To describe data on epidemiology, microbiology, clinical characteristics and
outcome of adult patients admitted in the intensive care unit (ICU) with secondary peritonitis …

Machine learning (ML) algorithms are increasingly applied in medical research and in
healthcare, gradually improving clinical practice. Among various applications of these novel …

Antibiotics are recognized widely for their benefits when used appropriately. However, they
are often used inappropriately despite the importance of responsible use within good clinical …

Appropriate antibiotic treatment for critically ill patients with serious Gram-negative infections
in the intensive care unit is crucial to minimize morbidity and mortality. Several new …

Blood infection can release toxic bacterial lipopolysaccharides (LPSs) into bloodstream,
trigger a series of inflammatory reactions, and eventually lead to multiple organ dysfunction …

The increasing prevalence of infections caused by antibiotic-resistant bacteria is a global
healthcare crisis. Understanding the spread of resistance is predicated on the surveillance …

The challenging severity of some infections, especially in critically ill patients, makes the
diffusion of antimicrobial drugs within tissues one of the cornerstones of chemotherapy. The …