Glycosylation of proteins is one of the most important PTMs, with more than half of all human
proteins estimated to be glycosylated. It is widely known that aberrant glycosylation has …

Fucosylation is a post-translational modification of glycans, proteins, and lipids that is
responsible for many biological processes. Fucose conjugation via α (1, 2), α (1, 3), α (1, 4) …

OBJECTIVE.: CD24 is an established marker for poor prognosis in ovarian and other
carcinomas. Acquisition of cytoplasmic CD24, as opposed to membranous expression, has …

Neoplastic lesions typically express specific carbohydrate antigens on glycolipids, mucins,
and other glycoproteins. Such antigens are often under epigenetic control and are subject to …

Aberrant glycosylation of glycoproteins and glycolipids of cancer cells, which correlates with
poor survival rates, is being exploited for the development of immunotherapies for cancer. In …

Sialyl Lewis x and sialyl Lewis a expression depends on sialyltransferases and
fucosyltransferases. In this study, we screened for major variations of sialyltransferases and …

Glycosylation change is one of the landmark events of tumor occurrence and development,
and tumor cells may be inhibited by regulating the aberrant expression of …

Exosomes consist of vesicles that are secreted by several human cells, including tumor cells
and neurons, and they are found in several biological fluids. Exosomes have characteristic …

Aberrant glycan epitopes are a classic hallmark of malignant transformation, yet their full
clinical potential in cancer diagnostics and therapeutics is yet to be realized. This is partly …

Aberrant glycosylation in tumours stem from altered glycosyltransferase (GT) gene
expression but can the expression profiles of these signature genes be used to classify …