This review is directed at understanding how neuronal death occurs in two distinct insults,
global ischemia and focal ischemia. These are the two principal rodent models for human …

Stroke most commonly results from occlusion of a major artery in the brain and typically
leads to the death of all cells within the affected tissue. Mitochondria are centrally involved in …

Background—This review article deals with the role of calcium in ischemic cell death. A
calcium-related mechanism was proposed more than two decades ago to explain cell …

Free radicals are highly reactive molecules generated predominantly during cellular
respiration and normal metabolism. Imbalance between cellular production of free radicals …

Anticholinesterase compounds, organophosphates (OPs) and carbamates (CMs) are
commonly used for a variety of purposes in agriculture and in human and veterinary …

Tissue infarction, involving death of essentially all cells within a part of the brain, is a
common pathology resulting from stroke and an important determinant of the long-term …

Neurons are metabolically active cells that generally are dependent on mitochondrial A TP
production to meet their energetic needs. In contrast, other cell types with a high energy …

The use and effectiveness of current stroke reperfusion therapies are limited by the
complications of reperfusion injury, which include increased cerebrovascular permeability …

Recent results have demonstrated that the spin trapping agent α-phenyl-N-tert-butyl nitrone
(PBN) reduces infarct volume in rats subjected to 2 hours of middle cerebral artery …

Background and Purpose—Ischemic brain injury is characterized by 2 temporally distinct but
interrelated phases: ischemia (primary energy failure) and reperfusion (secondary energy …