Bioactive peptides and proteins from centipede venoms

Y Han, PM Kamau, R Lai, L Luo - Molecules, 2022 - mdpi.com
Venoms are a complex cocktail of biologically active molecules, including peptides, proteins,
polyamide, and enzymes widely produced by venomous organisms. Through long-term …

Molecular evolution of gland cell types and chemical interactions in animals

A Brückner, J Parker - Journal of Experimental Biology, 2020 - journals.biologists.com
Across the Metazoa, the emergence of new ecological interactions has been enabled by the
repeated evolution of exocrine glands. Specialized glands have arisen recurrently and with …

Genome of the pincer wasp Gonatopus flavifemur reveals unique venom evolution and a dual adaptation to parasitism and predation

Y Yang, X Ye, C Dang, Y Cao, R Hong, YH Sun, S Xiao… - BMC biology, 2021 - Springer
Background Hymenoptera comprise extremely diverse insect species with extensive
variation in their life histories. The Dryinidae, a family of solitary wasps of Hymenoptera …

Phylogenetic analyses suggest centipede venom arsenals were repeatedly stocked by horizontal gene transfer

EAB Undheim, RA Jenner - Nature Communications, 2021 - nature.com
Venoms have evolved over a hundred times in animals. Venom toxins are thought to evolve
mostly by recruitment of endogenous proteins with physiological functions. Here we report …

Utilisation of compounds from venoms in drug discovery

CM Trim, LJ Byrne, SA Trim - Progress in Medicinal Chemistry, 2021 - Elsevier
Difficult drug targets are becoming the normal course of business in drug discovery,
sometimes due to large interacting surfaces or only small differences in selectivity regions …

Duvernoy's Gland Transcriptomics of the Plains Black-Headed Snake, Tantilla nigriceps (Squamata, Colubridae): Unearthing the Venom of Small Rear-Fanged …

EP Hofmann, RM Rautsaw, AJ Mason, JL Strickland… - Toxins, 2021 - mdpi.com
The venoms of small rear-fanged snakes (RFS) remain largely unexplored, despite
increased recognition of their importance in understanding venom evolution more broadly …

The arylsulfatase-and phospholipase-rich venom of the plutoniumid centipede Theatops posticus

AN Lane, PD Nash, SA Ellsworth, GS Nystrom… - Toxicon, 2023 - Elsevier
Research on centipede venoms has led to the discovery of a diverse array of novel proteins
and peptides, including those with homology to previously discovered toxin families (eg …

Selection Across the Three-Dimensional Structure of Venom Proteins from North American Scolopendromorph Centipedes

SA Ellsworth, RM Rautsaw, MJ Ward… - Journal of Molecular …, 2024 - Springer
Gene duplication followed by nucleotide differentiation is one of the simplest mechanisms to
develop new functions for genes. However, the evolutionary processes underlying the …

Anatomical constraints on venom and toxin evolution in centipedes

S Hverven - 2022 - duo.uio.no
Centipedes are among the oldest groups of venomous predatory arthropods. They have had
similar morphology and life history for many million years and can be compared with …