[HTML][HTML] Superantigen recognition and interactions: functions, mechanisms and applications
AM Deacy, SKE Gan, JP Derrick - Frontiers in Immunology, 2021 - frontiersin.org
Superantigens are unconventional antigens which recognise immune receptors outside
their usual recognition sites eg complementary determining regions (CDRs), to elicit a …
their usual recognition sites eg complementary determining regions (CDRs), to elicit a …
Staphylococcus aureus and its IgE-inducing enterotoxins in asthma: current knowledge
While immunoglobulin (Ig) E is a prominent biomarker for early-onset, its levels are often
elevated in non-allergic late-onset asthma. However, the pattern of IgE expression in the …
elevated in non-allergic late-onset asthma. However, the pattern of IgE expression in the …
Allosteric drugs and mutations: chances, challenges, and necessity
E Guarnera, IN Berezovsky - Current opinion in structural biology, 2020 - Elsevier
Highlights•Allosteric drugs have become an indispensable tool in precision medicine.•Major
targets for allosteric drugs: diversity structures and functions.•Allosteric effects of mutations …
targets for allosteric drugs: diversity structures and functions.•Allosteric effects of mutations …
Glyco engineered pentameric SARS-CoV-2 IgMs show superior activities compared to IgG1 orthologues
S Kallolimath, R Palt, E Föderl-Höbenreich… - Frontiers in …, 2023 - frontiersin.org
Immunoglobulin M (IgM) is the largest antibody isotype with unique features like extensive
glycosylation and oligomerization. Major hurdles in characterizing its properties are …
glycosylation and oligomerization. Major hurdles in characterizing its properties are …
Sagacity in antibody humanization for therapeutics, diagnostics and research purposes: considerations of antibody elements and their roles
The humanization of antibodies for therapeutics is a critical process that can determine the
success of antibody drug development. However, the science underpinning this process …
success of antibody drug development. However, the science underpinning this process …
Molecular insights of nickel binding to therapeutic antibodies as a possible new antibody superantigen
The binding of nickel by immune proteins can manifest as Type IV contact dermatitis (Ni-
specific T cells mediated) and less frequently as Type I hypersensitivity with both …
specific T cells mediated) and less frequently as Type I hypersensitivity with both …
Not all therapeutic antibody isotypes are equal: the case of IgM versus IgG in Pertuzumab and Trastuzumab
The therapeutic potential of immunoglobulin M (IgM) is of considerable interest in
immunotherapy due to its complement-activating and cell-agglutinating abilities …
immunotherapy due to its complement-activating and cell-agglutinating abilities …
Peering into avian influenza a (H5N8) for a framework towards pandemic preparedness
2014 marked the first emergence of avian influenza A (H5N8) in Jeonbuk Province, South
Korea, which then quickly spread worldwide. In the midst of the 2020–2021 H5N8 outbreak …
Korea, which then quickly spread worldwide. In the midst of the 2020–2021 H5N8 outbreak …
Computationally guided design of single-chain variable fragment improves specificity of chimeric antigen receptors
A Krokhotin, H Du, K Hirabayashi, K Popov… - Molecular Therapy …, 2019 - cell.com
Chimeric antigen receptor (CAR)-T cell-based immunotherapy of malignant disease relies
on the specificity and association constant of single-chain variable fragments (scFvs). The …
on the specificity and association constant of single-chain variable fragments (scFvs). The …
Sagacious epitope selection for vaccines, and both antibody-based therapeutics and diagnostics: tips from virology and oncology
The target of an antibody plays a significant role in the success of antibody-based
therapeutics and diagnostics, and vaccine development. This importance is focused on the …
therapeutics and diagnostics, and vaccine development. This importance is focused on the …