Pulmonary Fibrosis Stakeholder Summit: A Joint NHLBI, Three Lakes Foundation, and Pulmonary Fibrosis Foundation Workshop Report

SB Montesi, CR Gomez, M Beers, R Brown… - American Journal of …, 2024 - atsjournals.org
Despite progress in elucidation of disease mechanisms, identification of risk factors,
biomarker discovery, and the approval of two medications to slow lung function decline in …

Multiple-model-based robust estimation of causal treatment effect on a binary outcome with integrated information from secondary outcomes

C Chen, S Chen, Q Long, S Das… - The American …, 2024 - Taylor & Francis
An assessment of the causal treatment effect in the development and progression of certain
diseases is important in clinical trials and biomedical studies. However, it is not possible to …

An efficient data integration scheme for synthesizing information from multiple secondary datasets for the parameter inference of the main analysis

C Chen, M Wang, S Chen - Biometrics, 2023 - academic.oup.com
Many observational studies and clinical trials collect various secondary outcomes that may
be highly correlated with the primary endpoint. These secondary outcomes are often …

Online Data Collection for Efficient Semiparametric Inference

S Gupta, ZC Lipton, D Childers - arXiv preprint arXiv:2411.03195, 2024 - arxiv.org
While many works have studied statistical data fusion, they typically assume that the various
datasets are given in advance. However, in practice, estimation requires difficult data …

Integrating external summary information in the presence of prior probability shift: an application to assessing essential hypertension

C Chen, P Han, S Chen, M Shardell, J Qin - Biometrics, 2024 - academic.oup.com
Recent years have witnessed a rise in the popularity of information integration without
sharing of raw data. By leveraging and incorporating summary information from external …

Robust integration of secondary outcomes information into primary outcome analysis in the presence of missing data

DAQIDGQ Deng, VM Chinchilli… - … Methods in Medical …, 2024 - journals.sagepub.com
<? show [AQ ID= GQ2 POS=-20pt]?><? show [AQ ID= GQ4]?><? show [AQ ID= GQ5 POS=
12pt]?> In clinical and observational studies, secondary outcomes are frequently collected …

Synthesizing secondary data into survival analysis to improve estimation efficiency

C Chen, T Yu, B Shen, M Wang - Biometrical Journal, 2023 - Wiley Online Library
The accelerated failure time (AFT) model and Cox proportional hazards (PH) model are
broadly used for survival endpoints of primary interest. However, the estimation efficiency …

Leveraging information from secondary endpoints to enhance dynamic borrowing across subpopulations

JM Wolf, DM Vock, X Luo, DK Hatsukami… - …, 2024 - academic.oup.com
Randomized trials seek efficient treatment effect estimation within target populations, yet
scientific interest often also centers on subpopulations. Although there are typically too few …

Commentary on Chen et al.(2022): The need for continued methodological research on leveraging information in secondary endpoints for more efficient RCTs

JM Wolf, JS Koopmeiners, DM Vock - Contemporary Clinical Trials, 2024 - Elsevier
Abstract Chen et al.(2022) recently proposed a set of estimating equations that incorporate
data from secondary endpoints to improve precision in parameter estimates related to a …

Integrative data analysis where partial covariates have complex non-linear effects by using summary information from an external data

J Liang, S Chen, P Kochunov, LE Hong… - The American …, 2024 - Taylor & Francis
A full parametric and linear specification may be insufficient to capture complicated patterns
in studies exploring complex features, such as those investigating age-related changes in …