Fungal natural products in research and development

A Schueffler, T Anke - Natural product reports, 2014 - pubs.rsc.org
Covering: 2009 to 2013 To date approximately 100 000 fungal species are known although
far more than one million are expected. The variety of species and the diversity of their …

Natural sesquiterpene quinone/quinols: Chemistry, biological activity, and synthesis

XH Tian, LL Hong, WH Jiao, HW Lin - Natural Product Reports, 2023 - pubs.rsc.org
Covering: 2010 to 2021 Sesquiterpene quinone/quinols (SQs) are characterized by a C15-
sesquiterpenoid unit incorporating a C6-benzoquinone/quinol moiety. Numerous …

Impact of SMTP targeting plasminogen and soluble epoxide hydrolase on thrombolysis, inflammation, and ischemic stroke

K Hasumi, E Suzuki - International Journal of Molecular Sciences, 2021 - mdpi.com
Stachybotrys microspora triprenyl phenol (SMTP) is a large family of small molecules
derived from the fungus S. microspora. SMTP acts as a zymogen modulator (specifically …

Thrombolytic therapy for acute ischemic stroke: past and future

K Shibata, T Hashimoto, T Miyazaki… - Current …, 2019 - ingentaconnect.com
Background: Thromboembolic ischemic stroke, which is mainly caused by hypertension, as
well as plasma dyslipidemia, arterial fibrillation and diabetes, is a leading cause of death in …

SMTP-44D inhibits atherosclerotic plaque formation in apolipoprotein-E null mice partly by suppressing the AGEs-RAGE axis

M Terasaki, K Shibata, Y Mori, T Saito, T Matsui… - International Journal of …, 2023 - mdpi.com
SMTP-44D has been reported to have anti-oxidative and anti-inflammatory reactions,
including reduced expression of receptor for advanced glycation end products (RAGE) in …

Progress in isoindolone alkaloid derivatives from marine microorganism: Pharmacology, preparation, and mechanism

S Hang, H Chen, W Wu, S Wang, Y Fang, R Sheng… - Marine Drugs, 2022 - mdpi.com
Compound 1 (SMTP-7, also FGFC1), an isoindolone alkaloid from marine fungi Starchbotrys
longispora FG216 and fungi Stachybotrys microspora IFO 30018, possessed diverse …

SMTP-7, a novel small-molecule thrombolytic for ischemic stroke: a study in rodents and primates

H Sawada, N Nishimura, E Suzuki… - Journal of Cerebral …, 2014 - journals.sagepub.com
SMTP-7 (Stachybotrys microspora triprenyl phenol-7), a small molecule that promotes
plasminogen activation through the modulation of plasminogen conformation, has excellent …

Chemical and bioactive diversities of the genera Stachybotrys and Memnoniella secondary metabolites

A Wang, Y Xu, Y Gao, Q Huang, X Luo, H An… - Phytochemistry …, 2015 - Springer
During the course of search for novel and bioactive molecules of microbial origin for drug
development, Stachybotrys and Memnoniella fungi generally have been found to be a rich …

Soluble epoxide hydrolase as an anti-inflammatory target of the thrombolytic stroke drug SMTP-7

N Matsumoto, E Suzuki, M Ishikawa, T Shirafuji… - Journal of Biological …, 2014 - ASBMB
Although ischemic stroke is a major cause of death and disability worldwide, only a small
fraction of patients benefit from the current thrombolytic therapy due to a risk of cerebral …

Distinct effects of tissue-type plasminogen activator and SMTP-7 on cerebrovascular inflammation following thrombolytic reperfusion

T Miyazaki, Y Kimura, H Ohata, T Hashimoto, K Shibata… - Stroke, 2011 - Am Heart Assoc
Background and Purpose—Thrombolysis therapy using tissue-type plasminogen activator (t-
PA) is occasionally accompanied by harmful outcomes, including intracerebral hemorrhage …