One year into the global COVID-19 pandemic, the focus of attention has shifted to the
emergence and spread of SARS-CoV-2 variants of concern (VOCs). After nearly a year of …

Despite the slow evolutionary rate of SARS-CoV-2 relative to other RNA viruses, its massive
and rapid transmission during the COVID-19 pandemic has enabled it to acquire significant …

Two new SARS-CoV-2 lineages with the N501Y mutation in the receptor-binding domain of
the spike protein spread rapidly in the United Kingdom. We estimated that the earlier 501Y …

The persistent COVID-19 pandemic since 2020 has brought an enormous public health
burden to the global society and is accompanied by various evolution of the virus genome …

Recent waves of COVID-19 correlate with the emergence of the Delta and the Omicron
variant. We report that the Spike trimer acts as a highly dynamic molecular caliper, thereby …

In addition to the rapid, global spread of SARS-CoV-2, new and comparatively more
contagious variants are of considerable concern. These emerging mutations have become a …

The emerging N501Y mutation in severe acute respiratory syndrome coronavirus 2, which
becomes prevalent in the UK rapidly, is one of the major challenges of COVID-19 control. To …

Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic caused by it,
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been undergoing a …

In this study, we used an integrative computational approach to examine molecular
mechanisms and determine functional signatures underlying the role of functional residues …

Molecular Dynamics (MD) Simulations is increasingly used as a powerful tool to study
protein structure-related questions. Starting from the early simulation study on the …