Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection
HE Bøtker, D Hausenloy, I Andreadou… - Basic research in …, 2018 - Springer
The potential for ischemic preconditioning to reduce infarct size was first recognized more
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …
Cardiovascular metabolomics
RW McGarrah, SB Crown, GF Zhang, SH Shah… - Circulation …, 2018 - Am Heart Assoc
Disturbances in cardiac metabolism underlie most cardiovascular diseases. Metabolomics,
one of the newer omics technologies, has emerged as a powerful tool for defining changes …
one of the newer omics technologies, has emerged as a powerful tool for defining changes …
Biomarkers in heart failure: the past, current and future
M Sarhene, Y Wang, J Wei, Y Huang, M Li, L Li… - Heart failure …, 2019 - Springer
Despite the enhanced knowledge of the pathophysiology of heart failure (HF), it still remains
a serious syndrome with substantial morbidity, mortality, and frequent hospitalizations …
a serious syndrome with substantial morbidity, mortality, and frequent hospitalizations …
Epigenetic-sensitive pathways in personalized therapy of major cardiovascular diseases
The complex pathobiology underlying cardiovascular diseases (CVDs) has yet to be
explained. Aberrant epigenetic changes may result from alterations in enzymatic activities …
explained. Aberrant epigenetic changes may result from alterations in enzymatic activities …
Galectin-3 in heart failure: an update of the last 3 years
C Gehlken, N Suthahar, WC Meijers… - Heart failure …, 2018 - heartfailure.theclinics.com
This article provides an update regarding the most recent published literature on galectin-3
as a biomarker in heart failure (HF) and gives an outlook toward its use as a biotarget. 1 In …
as a biomarker in heart failure (HF) and gives an outlook toward its use as a biotarget. 1 In …
Balancing the Equation: A Natural History of Trimethylamine and Trimethylamine-N-oxide
Trimethylamine (TMA) and its N-oxide (TMAO) are ubiquitous in prokaryote and eukaryote
organisms as well as in the environment, reflecting their fundamental importance in …
organisms as well as in the environment, reflecting their fundamental importance in …
Lipid metabolite biomarkers in cardiovascular disease: Discovery and biomechanism translation from human studies
P McGranaghan, JA Kirwan, MA Garcia-Rivera… - Metabolites, 2021 - mdpi.com
Lipids represent a valuable target for metabolomic studies since altered lipid metabolism is
known to drive the pathological changes in cardiovascular disease (CVD). Metabolomic …
known to drive the pathological changes in cardiovascular disease (CVD). Metabolomic …
Prognostic significance of metabolomic biomarkers in patients with diabetes mellitus and coronary artery disease
Background Diabetes mellitus (DM) and coronary artery disease (CAD) constitute inter-
related clinical entities. Biomarker profiling emerges as a promising tool for the early …
related clinical entities. Biomarker profiling emerges as a promising tool for the early …
Plasma metabolomic profiling in subclinical atherosclerosis: the Diabetes Heart Study
PA Chevli, BI Freedman, FC Hsu, J Xu… - Cardiovascular …, 2021 - Springer
Background Incidence rates of cardiovascular disease (CVD) are increasing, partly driven
by the diabetes epidemic. Novel prediction tools and modifiable treatment targets are …
by the diabetes epidemic. Novel prediction tools and modifiable treatment targets are …
Precision Medicine in the Management of Dilated Cardiomyopathy: JACC State-of-the-Art Review
D Fatkin, IG Huttner, JC Kovacic, JG Seidman… - Journal of the American …, 2019 - jacc.org
Precision medicine promises to dramatically improve patient outcomes and reduce health
care costs through a shift in focus from disease treatment to prevention and individualized …
care costs through a shift in focus from disease treatment to prevention and individualized …