Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …

Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Resetting tumor-associated macrophages (TAMs) is a promising strategy to ameliorate the
immunosuppressive tumor microenvironment and improve innate and adaptive antitumor …

In the last 5 years, most of the molecules that control mitochondrial Ca2+ homeostasis have
been finally identified. Mitochondrial Ca2+ uptake is mediated by the Mitochondrial Calcium …

Calcium (Ca 2+) is considered one of the most-important biological cations, because it is
implicated in cell physiopathology and cell fate through a finely tuned signaling system. In …

Mitochondrial Ca 2+ regulation is crucial for bioenergetics and cellular signaling. The
mechanisms controlling mitochondrial calcium homeostasis have been recently unraveled …

Mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) are morpho-functional
units, formed at the loci of close apposition of the ER-forming endomembrane and outer …

Consumption of adenosine triphosphate (ATP) by the heart can change dramatically as the
energetic demands increase from a period of rest to strenuous activity. Mitochondrial ATP …

In the mammalian brain, a family of sodium-dependent transporters maintains low
extracellular glutamate and shapes excitatory signaling. The bulk of this activity is mediated …

Astrocytes are the major glial cell in the central nervous system. These polarized cells
possess numerous processes that ensheath the vasculature and contact synapses …