Role of lipid accumulation and inflammation in atherosclerosis: focus on molecular and cellular mechanisms

K Malekmohammad, EE Bezsonov… - Frontiers in …, 2021 - frontiersin.org
Atherosclerosis is a chronic lipid-driven and maladaptive inflammatory disease of arterial
intima. It is characterized by the dysfunction of lipid homeostasis and signaling pathways …

Interleukin-6 in atherosclerosis: atherogenic or atheroprotective?

AB Reiss, NM Siegart, J De Leon - Clinical Lipidology, 2017 - Taylor & Francis
ABSTRACT Interleukin-6 (IL-6) is a unique pleiotropic cytokine exhibiting both pro-and anti-
inflammatory properties depending on the target cell type. Plasma IL-6 levels are associated …

CircRNA‑0044073 is upregulated in atherosclerosis and increases the proliferation and invasion of cells by targeting miR‑107

L Shen, Y Hu, J Lou, S Yin… - Molecular …, 2019 - spandidos-publications.com
Circular RNAs (circRNAs) are endogenous non‑coding RNAs implicated in atherosclerosis.
The aim of the present study was to explore the function of circRNA‑0044073 in …

CircRNA–miRNA interactions in atherogenesis

KL Tong, KE Tan, YY Lim, XY Tien, PF Wong - Molecular and cellular …, 2022 - Springer
Atherosclerosis is the major cause of coronary artery disease (CAD) which includes
unstable angina, myocardial infarction, and heart failure. The onset of atherogenesis, a …

[HTML][HTML] MIAT promotes proliferation and hinders apoptosis by modulating miR-181b/STAT3 axis in ox-LDL-induced atherosclerosis cell models

X Zhong, X Ma, L Zhang, Y Li, Y Li, R He - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Background Plenty of lncRNAs and microRNAs have been identified to be critical mediators
in the progression of atherosclerosis (AS). Myocardial infarction-associated transcript (MIAT) …

[HTML][HTML] Irigenin treatment alleviates doxorubicin (DOX)-induced cardiotoxicity by suppressing apoptosis, inflammation and oxidative stress via the increase of miR …

L Guo, X Zheng, E Wang, X Jia, G Wang… - Biomedicine & …, 2020 - Elsevier
Doxorubicin (DOX) is an eff; ective chemotherapeutic drug to suppress the progression of
various types of tumors. However, its clinical application has been largely limited due to its …

[HTML][HTML] S-glutathionylation, friend or foe in cardiovascular health and disease

NA Rashdan, B Shrestha, CB Pattillo - Redox Biology, 2020 - Elsevier
Glutathione is a low molecular weight thiol that is present at high levels in the cell. The high
levels of glutathione in the cell make it one of the most abundant antioxidants contributing to …

Exenatide mitigated diet-induced vascular aging and atherosclerotic plaque growth in ApoE-deficient mice under chronic stress

G Yang, Y Lei, A Inoue, L Piao, L Hu, H Jiang, T Sasaki… - Atherosclerosis, 2017 - Elsevier
Background and aims Exposure to psychosocial stress is a risk factor for cardiovascular
disorders. Because the glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonist prevents …

The role of hyperuricemia on vascular endothelium dysfunction

H Zhen, F Gui - Biomedical reports, 2017 - spandidos-publications.com
Hyperuricemia appears to be associated with an increased risk for cardiovascular disease
and associated mortality. Population epidemiological data support a causal link between …

Lysosome (Dys) function in atherosclerosis—a big weight on the shoulders of a small organelle

ARA Marques, C Ramos… - Frontiers in cell and …, 2021 - frontiersin.org
Atherosclerosis is a progressive insidious chronic disease that underlies most of the
cardiovascular pathologies, including myocardial infarction and ischemic stroke. The …