Gene-engineered immune cell therapies have partially transformed cancer treatment, as
exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic …

Cancer kills millions of individuals every year all over the world (Global Cancer
Observatory). The physiological and biomechanical processes underlying the tumor are still …

The rates and patterns of somatic mutation in normal tissues are largely unknown outside of
humans,,,,,–. Comparative analyses can shed light on the diversity of mutagenesis across …

The complexity, diversity, and heterogeneity of malignant tumors pose a formidable
challenge for antitumor therapy. To achieve the goal of significantly enhancing the antitumor …

In population studies, dietary patterns clearly influence the development, progression, and
therapeutic response of cancers. Nonetheless, interventional dietary trials have had …

Aging is a nearly inescapable trait among organisms yet lifespan varies tremendously
across different species and spans several orders of magnitude in vertebrates alone. This …

Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-lived rodents with a
maximum life span exceeding 37 years. They exhibit a delayed aging phenotype and …

Evolutionary medicine–ie the application of insights from evolution and ecology–has
tremendous untapped potential to spark transformational innovation in biomedicine and …

Cancer is one of the major causes of death globally. Currently, various methods are used to
treat cancer, including radiotherapy, surgery, and chemotherapy, all of which have serious …

Background & Aims In the mouse intestinal epithelium, Lgr5+ stem cells are vulnerable to
injury, owing to their predominantly cycling nature, and their progenies de-differentiate to …