Non-peptidic inhibitors targeting SARS-CoV-2 main protease: A review

YQ Xiao, J Long, SS Zhang, YY Zhu, SX Gu - Bioorganic Chemistry, 2024 - Elsevier
The COVID-19 pandemic continues to pose a threat to global health, and sounds the alarm
for research & development of effective anti-coronavirus drugs, which are crucial for the …

[HTML][HTML] The Design, Synthesis and Mechanism of Action of Paxlovid, a Protease Inhibitor Drug Combination for the Treatment of COVID-19

M Bege, A Borbás - Pharmaceutics, 2024 - mdpi.com
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), has presented an enormous challenge to health care systems and medicine …

[HTML][HTML] Applications of Molecular Docking Studies in SARS-CoV-2 Targeted Drug Discovery and the Gains Achieved through Molecular Docking

M Yildirim, I Celik - 2024 - intechopen.com
In this chapter, we delve into the pivotal role of molecular docking in the realm of
computational biology and chemistry, focusing specifically on its application in drug …

In Silico Development of SARS-CoV-2 Non-covalent Mpro Inhibitors: A Review

I Alagawani, F Wang - 2024 - preprints.org
Coronaviruses (CoVs) have recently emerged as significant causes of respiratory disease
outbreaks. The novel coronavirus pneumonia of 2019, known as COVID-19, are highly …