Since the pioneering works of Kaliszan (R. Kaliszan, Quantitative Structure–
Chromatographic Retention Relationships, Wiley, New York, 1987; and R. Kaliszan …

Abstract Drug binding to Human Serum Albumin (HSA) is an area of intense research. The
pharmacokinetics and pharmacodynamics of drugs are strongly affected by their binding to …

Plasma protein binding (PPB) strongly affects drug distribution and pharmacokinetic
behavior with consequences in overall pharmacological action. Extended plasma protein …

Chiral drugs show distinct biochemical and pharmacological behaviors in the human body.
The binding of chiral drugs to plasma proteins usually exhibits stereoselectivity, which has a …

Most will agree that one major achievement in the bio-separation techniques is affinity
chromatography. This coined terminology covers a myriad of separation approaches that …

The binding of drugs with proteins in blood, serum, or plasma is an important process in
determining the activity, distribution, rate of excretion, and toxicity of drugs in the body. High …

Tandem mass spectrometry (MS/MS), in particular high-resolution MS/MS, is able to provide
element compositions and substructures for the detected signals. However, it is still …

The binding of drugs with serum proteins can affect the activity, distribution, rate of excretion,
and toxicity of pharmaceutical agents in the body. One tool that can be used to quickly …

This review addresses the use of high-performance liquid chromatography (HPLC) and
capillary electrophoresis (CE) as affinity separation methods to characterise drugs or …

Plasma protein binding has a profound impact on the pharmacokinetic and
pharmacodynamic properties of many drug candidates and is thus an integral component of …