Gliomas are a diverse group of primary central nervous system neoplasms with no curative
therapies available. Brain macrophages comprise microglia in the brain parenchyma, border …

The phenomenon of accumulation of senescent adaptive immunity cells in the elderly is
attracting attention due to the increasing risk of global epidemics and aging of the global …

Hypersynchronous and exaggerated neuronal firing, exemplified by epileptiform activity and
seizures, are disruptors of brain function across acute and chronic neuropathological …

Almost 16% of the global population is affected by neurological disorders, including
neurodegenerative and cerebral neuroimmune diseases, triggered by acute or chronic …

Research question Is there a protective effect of the humanin derivative [Gly14]-humanin
(HNG) on a D-gal-induced mouse model of primary ovarian insufficiency (POI), and what is …

Metabolic disorders are considered the hallmarks of cancer and metabolic reprogramming is
emerging as a new strategy for cancer treatment. Exogenous and endogenous stressors can …

Objective Intervertebral disc degeneration (IVDD) constitutes a crucial pathological
foundation for spinal degenerative diseases (SDD) and stands as a primary contributor to …

Cellular senescence is a natural barrier of the transition from premalignant cells to invasive
cancer. Pharmacological induction of senescence has been proposed as a possible …

In Alzheimer's disease (AD), tau dissociates from microtubules (MTs) due to
hyperphosphorylation and misfolding. It is degraded by various mechanisms, including the …

The clinical prevention, diagnosis, treatment, and drug development of Alzheimer's disease
(AD) require urgent detection of novel targets and methods. Autophagy and microglia are …