The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) have pleiotropic
effects in multiple organs including brain, heart, and skeletal muscle by serving as an …

Alveolar hypoxia is the most prominent feature of high altitude environment with well-known
consequences for the cardio-pulmonary system, including development of pulmonary …

Studies have shown significantly increased thromboembolic events at high altitude. We
recently reported that transferrin could potentiate blood coagulation, but the underlying …

Iron deficiency impairs skeletal muscle metabolism. The underlying mechanisms are
incompletely characterised, but animal and human experiments suggest the involvement of …

Key points Iron acts as a cofactor in the stabilization of the hypoxic‐inducible factor family,
and plays an influential role in the modulation of hypoxic pulmonary vasoconstriction. It is …

Cardiovascular function and adipose metabolism were markedly influenced under high
altitudes. However, the interplay between adipokines and heart under hypoxia remains to be …

High-altitude (HA) exposure may stimulate significant physiological and molecular changes,
resulting in HA-related illnesses. HA may impact oxidative stress, antioxidant capacity, and …

Introduction HIF-1α, a key player in medical science, holds immense significance in
therapeutic approaches. This review delves into its complex dynamics, emphasizing the …

Remote ischemic preconditioning (RIPC) may improve exercise performance. However, the
influence of RIPC on aerobic performance and underlying physiological mechanisms during …

Background Increasing iron bioavailability attenuates hypoxic pulmonary vasoconstriction in
both lowlanders and Sherpas at high altitude. In contrast, the pulmonary vasculature of …