The AMPK pathway in fatty liver disease

C Fang, J Pan, N Qu, Y Lei, J Han, J Zhang… - Frontiers in …, 2022 - frontiersin.org
Lipid metabolism disorders are the primary causes for the occurrence and progression of
various liver diseases, including non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty …

[HTML][HTML] Nuclear factor erythroid 2-related factor 2-mediated signaling and metabolic associated fatty liver disease

VN Bukke, A Moola, G Serviddio… - World journal of …, 2022 - ncbi.nlm.nih.gov
Oxidative stress is a key driver in the development and progression of several diseases,
including metabolic associated fatty liver disease (MAFLD). This condition includes a wide …

Moderate wine consumption and health: a narrative review

S Hrelia, L Di Renzo, L Bavaresco, E Bernardi… - Nutrients, 2022 - mdpi.com
Although it is clearly established that the abuse of alcohol is seriously harmful to health,
much epidemiological and clinical evidence seem to underline the protective role of …

Targeting NRF2–KEAP1 axis by Omega-3 fatty acids and their derivatives: Emerging opportunities against aging and diseases

S Davinelli, A Medoro, M Intrieri, L Saso… - Free Radical Biology …, 2022 - Elsevier
The transcription factor NRF2 and its endogenous inhibitor KEAP1 play a crucial role in the
maintenance of cellular redox homeostasis by regulating the gene expression of diverse …

[HTML][HTML] Resveratrol relieves chronic heat stress-induced liver oxidative damage in broilers by activating the Nrf2-Keap1 signaling pathway

KN Ding, MH Lu, YN Guo, SS Liang, RW Mou… - Ecotoxicology and …, 2023 - Elsevier
Heat stress (HS) affects poultry production and welfare, causing enormous damage to
poultry. Resveratrol, an antioxidant and anti-inflammatory natural plant polyphenol, is widely …

Effect of natural polysaccharides on alcoholic liver disease: A review

S Li, X Zhou, R Chen, Q Zhang, Y Sun… - International Journal of …, 2023 - Elsevier
In this study, we systematically collected relevant literature in the past five years on the
intervention of natural polysaccharides in alcoholic liver disease (ALD) and reviewed the …

The coumarin-derivative esculetin protects against lipotoxicity in primary rat hepatocytes via attenuating jnk-mediated oxidative stress and attenuates free fatty acid …

M Xia, Z Wu, J Wang, M Buist-Homan, H Moshage - Antioxidants, 2023 - mdpi.com
Coumarin derivates have been proposed as a potential treatment for metabolic-dysfunction-
associated fatty liver disease (MAFLD). However, the mechanisms underlying their …

Lycopene alleviates chronic stress-induced liver injury by inhibiting oxidative stress-mediated endoplasmic reticulum stress pathway apoptosis in rats

N Sun, T Yang, Y Tang, Y Zhao, H Wang… - Journal of Agricultural …, 2022 - ACS Publications
The liver is the major organ of metabolism and is extremely vulnerable to chronic stress.
Lycopene (LYC) is a natural carotenoid with potent antioxidant and chronic disease …

The roles of NFR2-regulated oxidative stress and mitochondrial quality control in chronic liver diseases

JS Park, N Rustamov, YS Roh - Antioxidants, 2023 - mdpi.com
Chronic liver disease (CLD) affects a significant portion of the global population, leading to a
substantial number of deaths each year. Distinct forms like non-alcoholic fatty liver disease …

Naringin ameliorates liver fibrosis in zebrafish by modulating IDO1-mediated lipid metabolism and inflammatory infiltration

M Qin, J Li, Y Zheng, Y Li, Y Zhang, R Ou, W He… - Food & Function, 2023 - pubs.rsc.org
Liver fibrosis (LF) is an important reparative process in response to acute or chronic hepatic
injury, which has the potential to advance towards cirrhosis and hepatocellular carcinoma …