Oxaliplatin (cyclohexane-1, 2-diamine; oxalate; platinum [2+]) is a third-generation
chemotherapeutic drug with anticancer effects. Oxaliplatin has a role in the treatment of …

Chronic pain, including cancer-related pain, is a pain condition often caused by
inflammation or dysfunctional nerves. Chronic pain treatment poses a significant health care …

The capacity of neurons to develop a long axon and multiple dendrites defines neuron
connectivity in the CNS. The highly conserved microRNA-9 (miR-9) is expressed in both …

Background Neurons extend their dendrites and axons to build functional neural circuits,
which are regulated by both positive and negative signals during development. Brain …

Chemotherapy drugs such as vincristine (Vin) could cause neuropathic pain. However, it is
still lack of ideal therapeutic strategy to treat it. Mitochondrial dysfunction has been involved …

Cancer pain remains a major challenge and there is an urgent demand for the development
of specific mechanism‐based therapies. Various diseases are associated with unique …

Pain is an important protective system that alerts organisms to actual or possible tissue
damage. However, a variety of pathologies can lead to chronic pain that is no longer …

Maspin is a tumor and metastasis suppressor playing an essential role as gatekeeper of
tumor progression. It is highly expressed in epithelial cells but is silenced in the onset of …

Chronic neuropathic pain is associated with global changes in gene expression in different
areas of the nociceptive pathway. MicroRNAs (miRNAs) are small (~ 22 nt long) non-coding …

Recognition of overlapping molecular signaling activated by a chemical trigger of cancer
and neurodegeneration is new, but the path to this discovery has been long and potholed …