BACKGROUND: Non-surgical management of anal cancer by radiotherapy alone or
combined with chemotherapy has, in uncontrolled studies, yielded similar local tumour …

Squamous cell carcinoma of the anal canal serves as a paradigm for the successful
application of multimodality treatment of solid tumors. Since 1974, multimodality treatment …

The second factor that has resulted in a paradigm shift in understanding the etiology of anal
cancer is the discovery that the human papilloma virus (HPV), especially HPV serotypes 16 …

Purpose To define the optimal treatment of patients with squamous cell carcinoma (SCCA)
of the anal margin. Methods Nineteen patients treated with curative intent by radiotherapy …

Abstract From 1972 to 1985, 260 cases of anal canal epidermoid carcinoma were irradiated.
Eighteen cases treated for palliation were excluded from the study; 242 (93%) were treated …

The study of 54 patients treated curatively by irradiation with or without surgery is reported.
The crude and cancer-specific five-year survival rates are 59.2 percent and 79.7 percent …

Summary Background Chemotherapy (5-fluorouracil-mitomycin C) concomitant with
radiotherapy (RT) increases local control and colostomy-free survival in advanced anal …

A large variety of neoplasms are found in the anal canal and perianal region. Most are
distinctly uncommon and may, therefore, pose the question of suitable therapy. For some …

Purpose: To evaluate (a) long-term survival and (b) the incidence and nature of long-term
morbidity/mortality related to chemoradiation using teh anal cancer experience. Methods …

Anal cancer is a rare malignancy that accounts for 2% of all colorectal malignancy.
Approximately 5200 cases are diagnosed annually in the United States, resulting in more …