Sulfur plays a critical role for the development and maintenance of life on earth, which is
reflected by the wealth of primary metabolites, macromolecules, and cofactors bearing this …

The γ-lactam moiety is present in a large number of natural and non-natural biologically
active compounds. The range of biological activities covered by these compounds is very …

Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …

Microorganisms have a long track record as important sources of novel bioactive natural
products, particularly in the field of drug discovery. While microbes have been shown to …

Rationale: Growing evidence indicates that intracellular reactive oxygen species (ROS)
accumulation is a critical factor in the development of osteoporosis by triggering osteoclast …

Section Flavi encompasses both harmful and beneficial Aspergillus species, such as
Aspergillus oryzae, used in food fermentation and enzyme production, and Aspergillus …

Covering: 2006 to mid-2010 Marine-derived fungi continue to produce structurally unique
secondary metabolites, a considerable number of which display promising biological and …

Abstract Background The fungal genus Aspergillus is of critical importance to humankind.
Species include those with industrial applications, important pathogens of humans, animals …

Background Secondary metabolite production, a hallmark of filamentous fungi, is an
expanding area of research for the Aspergilli. These compounds are potent chemicals …

The iterative type I polyketide synthases (IPKSs) are central to the biosynthesis of an
enormously diverse array of natural products in fungi. These natural products, known as …