Biomimetic engineering of nonribosomal peptide synthesis
K Zhang, H Kries - Biochemical Society Transactions, 2023 - portlandpress.com
Nonribosomal peptides (NRPs) have gained attention due to their diverse biological
activities and potential applications in medicine and agriculture. The natural diversity of …
activities and potential applications in medicine and agriculture. The natural diversity of …
Investigating the role of class I adenylate-forming enzymes in natural product biosynthesis
HK D'Ambrosio, ER Derbyshire - ACS Chemical Biology, 2019 - ACS Publications
Adenylate-forming enzymes represent one of the most important enzyme classes in biology,
responsible for the activation of carboxylate substrates for biosynthetic modifications. The …
responsible for the activation of carboxylate substrates for biosynthetic modifications. The …
Protein engineering for natural product biosynthesis and synthetic biology applications
MA Calzini, AA Malico, MM Mitchler… - … , Design and Selection, 2021 - academic.oup.com
As protein engineering grows more salient, many strategies have emerged to alter protein
structure and function, with the goal of redesigning and optimizing natural product …
structure and function, with the goal of redesigning and optimizing natural product …
[HTML][HTML] Functional Diversity and Engineering of the Adenylation Domains in Nonribosomal Peptide Synthetases
M Zhang, Z Peng, Z Huang, J Fang, X Li, X Qiu - Marine Drugs, 2024 - mdpi.com
Nonribosomal peptides (NRPs) are biosynthesized by nonribosomal peptide synthetases
(NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs …
(NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs …
Characterization of a unique interrupted adenylation domain that can catalyze three reactions
Interrupted adenylation (A) domains contain auxiliary domains within their structure and are
a subject of growing interest in the field of nonribosomal peptide biosynthesis. They have …
a subject of growing interest in the field of nonribosomal peptide biosynthesis. They have …
[HTML][HTML] A thorough analysis and categorization of bacterial interrupted adenylation domains, including previously unidentified families
Interrupted adenylation (A) domains are key to the immense structural diversity seen in the
nonribosomal peptide (NRP) class of natural products (NPs). Interrupted A domains are A …
nonribosomal peptide (NRP) class of natural products (NPs). Interrupted A domains are A …
Unimodular Methylation by Adenylation–Thiolation Domains Containing an Embedded Methyltransferase
Nonribosomal peptides (NRPs) are natural products that are biosynthesized by large multi-
enzyme assembly lines called nonribosomal peptide synthetases (NRPSs). We have …
enzyme assembly lines called nonribosomal peptide synthetases (NRPSs). We have …
[HTML][HTML] Lessons learned in engineering interrupted adenylation domains when attempting to create trifunctional enzymes from three independent monofunctional …
Interrupted adenylation (A) domains are fascinating examples of multifunctional enzymes.
They are found in nonribosomal peptide synthetases (NRPSs), which biosynthesize …
They are found in nonribosomal peptide synthetases (NRPSs), which biosynthesize …
Characterization and Engineering of Interrupted Adenylation Domains
TA Lundy - 2020 - uknowledge.uky.edu
Nature has historically served as a prolific source of biologically active molecules produced
by plants, fungi, and bacteria termed natural products (NPs). These NPs often serve as …
by plants, fungi, and bacteria termed natural products (NPs). These NPs often serve as …