Nonribosomal peptides (NRPs) have gained attention due to their diverse biological
activities and potential applications in medicine and agriculture. The natural diversity of …

Adenylate-forming enzymes represent one of the most important enzyme classes in biology,
responsible for the activation of carboxylate substrates for biosynthetic modifications. The …

As protein engineering grows more salient, many strategies have emerged to alter protein
structure and function, with the goal of redesigning and optimizing natural product …

Nonribosomal peptides (NRPs) are biosynthesized by nonribosomal peptide synthetases
(NRPSs) and are widely distributed in both terrestrial and marine organisms. Many NRPs …

Interrupted adenylation (A) domains contain auxiliary domains within their structure and are
a subject of growing interest in the field of nonribosomal peptide biosynthesis. They have …

Interrupted adenylation (A) domains are key to the immense structural diversity seen in the
nonribosomal peptide (NRP) class of natural products (NPs). Interrupted A domains are A …

Nonribosomal peptides (NRPs) are natural products that are biosynthesized by large multi-
enzyme assembly lines called nonribosomal peptide synthetases (NRPSs). We have …

Interrupted adenylation (A) domains are fascinating examples of multifunctional enzymes.
They are found in nonribosomal peptide synthetases (NRPSs), which biosynthesize …

Nature has historically served as a prolific source of biologically active molecules produced
by plants, fungi, and bacteria termed natural products (NPs). These NPs often serve as …