Autism spectrum disorder: neuropathology and animal models

M Varghese, N Keshav, S Jacot-Descombes… - Acta …, 2017 - Springer
Autism spectrum disorder (ASD) has a major impact on the development and social
integration of affected individuals and is the most heritable of psychiatric disorders. An …

The neuropathology of autism: A systematic review of post-mortem studies of autism and related disorders

R Fetit, RF Hillary, DJ Price, SM Lawrie - Neuroscience & Biobehavioral …, 2021 - Elsevier
Post-mortem studies allow for the direct investigation of brain tissue in those with autism and
related disorders. Several review articles have focused on aspects of post-mortem …

FOXG1-dependent dysregulation of GABA/glutamate neuron differentiation in autism spectrum disorders

J Mariani, G Coppola, P Zhang, A Abyzov, L Provini… - Cell, 2015 - cell.com
Autism spectrum disorder (ASD) is a disorder of brain development. Most cases lack a clear
etiology or genetic basis, and the difficulty of re-enacting human brain development has …

Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons

ST Schafer, ACM Paquola, S Stern, D Gosselin… - Nature …, 2019 - nature.com
Autism spectrum disorder (ASD) is thought to emerge during early cortical development.
However, the exact developmental stages and associated molecular networks that prime …

Modulation of prefrontal cortex excitation/inhibition balance rescues social behavior in CNTNAP2-deficient mice

A Selimbeyoglu, CK Kim, M Inoue, SY Lee… - Science translational …, 2017 - science.org
Alterations in the balance between neuronal excitation and inhibition (E: I balance) have
been implicated in the neural circuit activity–based processes that contribute to autism …

The cerebellar involvement in autism spectrum disorders: from the social brain to mouse models

L Mapelli, T Soda, E D'Angelo, F Prestori - International journal of …, 2022 - mdpi.com
Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders that include
a variety of forms and clinical phenotypes. This heterogeneity complicates the clinical and …

Salience network–based classification and prediction of symptom severity in children with autism

LQ Uddin, K Supekar, CJ Lynch, A Khouzam… - JAMA …, 2013 - jamanetwork.com
Importance Autism spectrum disorder (ASD) affects 1 in 88 children and is characterized by
a complex phenotype, including social, communicative, and sensorimotor deficits. Autism …

Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism

RP Patrick, BN Ames - The FASEB Journal, 2014 - Wiley Online Library
Serotonin and vitamin D have been proposed to play a role in autism; however, no causal
mechanism has been established. Here, we present evidence that vitamin D hormone …

Resting state EEG abnormalities in autism spectrum disorders

J Wang, J Barstein, LE Ethridge, MW Mosconi… - Journal of …, 2013 - Springer
Autism spectrum disorders (ASD) are a group of complex and heterogeneous
developmental disorders involving multiple neural system dysfunctions. In an effort to …

Embodiment and sense-making in autism

H De Jaegher - Frontiers in integrative neuroscience, 2013 - frontiersin.org
In this article, I sketch an enactive account of autism. For the enactive approach to cognition,
embodiment, experience, and social interaction are fundamental to understanding mind and …