Studies of psychiatric disorders have traditionally focused on emotional symptoms such as
depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are …

Schizophrenia is a severe chronic psychiatric illness, characterized by hallucinations and
delusions. Decreased brain volumes have been observed in the disease, although the …

Importance Alterations in glutamatergic neurotransmission may be fundamental to the
pathophysiology of schizophrenia, and the glutamatergic system is a target for novel …

Neurons in the primate dorsolateral prefrontal cortex (dlPFC) generate persistent firing in the
absence of sensory stimulation, the foundation of mental representation. Persistent firing …

Schizophrenia is a chronic disorder characterized by specific positive and negative primary
symptoms, social behavior disturbances and cognitive deficits (eg, impairment in working …

Introduction: Resistance to antipsychotic treatment is a significant clinical problem in patients
with schizophrenia with approximately 1 in 3 showing limited or no response to repeated …

It is evident that once psychosis is present in patients with schizophrenia, the underlying
biological process of the illness has already been ongoing for many years. At the time of …

In schizophrenia, abnormal neural metabolite concentrations may arise from cortical
damage following neuroinflammatory processes implicated in acute episodes. Inflammation …

Currently, all treatments for schizophrenia (SCZ) function primarily by blocking D 2-type
dopamine receptors. Given the limitations of these medications, substantial efforts have …

Over more than 30 years in vivo MR spectroscopic imaging (MRSI) has undergone an
enormous evolution from theoretical concepts in the early 1980s to the robust imaging …