Research over the past several decades has unmasked a major contribution of disrupted
chromatin regulatory processes to human disease, particularly cancer. Advances in genome …

Chromatin functions are influenced by the addition, removal, and recognition of histone post-
translational modifications (PTMs). Ubiquitin and ubiquitin-like (UBL) PTMs on histone …

Cellular DNA is constantly being damaged by numerous internal and external mutagenic
factors. Probably the most severe type of insults DNA could suffer are the double-strand …

B-cell-specific Moloney murine leukemia virus integration region 1 (Bmi-1, also known as
RNF51 or PCGF4) is one of the important members of the PcG gene family, and is involved …

Distant recurrences occurring years after removal of the primary tumor arise from
disseminated tumor cells (DTCs) that lie dormant (quiescent/asymptomatic) until they …

In recent decades, cancer stem cells (CSCs) have been increasingly identified in many
malignancies. CSC-related signaling pathways and their functions provide new strategies …

Epigenetic mechanisms are crucial for sustaining cell type–specific transcription programs.
Among the distinct factors, Polycomb group (PcG) proteins are major negative regulators of …

Simple Summary Gene expression is primarily controlled at the level of transcription, largely
due to binding of transcription factors to specific sites on DNA, namely super-enhancers and …

Histone ubiquitination is a critical epigenetic mechanism regulating DNA-driven processes
such as gene transcription and DNA damage repair. Importantly, the cellular machinery …

Abstract The Polycomb group (PcG) proteins are a family of chromatin regulators and critical
for the maintenance of cellular identity. The PcG machinery can be categorized into at least …