Chromatin regulatory mechanisms and therapeutic opportunities in cancer
AM Valencia, C Kadoch - Nature cell biology, 2019 - nature.com
Research over the past several decades has unmasked a major contribution of disrupted
chromatin regulatory processes to human disease, particularly cancer. Advances in genome …
chromatin regulatory processes to human disease, particularly cancer. Advances in genome …
Chromatin regulation through ubiquitin and ubiquitin-like histone modifications
Chromatin functions are influenced by the addition, removal, and recognition of histone post-
translational modifications (PTMs). Ubiquitin and ubiquitin-like (UBL) PTMs on histone …
translational modifications (PTMs). Ubiquitin and ubiquitin-like (UBL) PTMs on histone …
The chromatin response to double-strand DNA breaks and their repair
Cellular DNA is constantly being damaged by numerous internal and external mutagenic
factors. Probably the most severe type of insults DNA could suffer are the double-strand …
factors. Probably the most severe type of insults DNA could suffer are the double-strand …
The crucial roles of Bmi-1 in cancer: implications in pathogenesis, metastasis, drug resistance, and targeted therapies
J Xu, L Li, P Shi, H Cui, L Yang - International Journal of Molecular …, 2022 - mdpi.com
B-cell-specific Moloney murine leukemia virus integration region 1 (Bmi-1, also known as
RNF51 or PCGF4) is one of the important members of the PcG gene family, and is involved …
RNF51 or PCGF4) is one of the important members of the PcG gene family, and is involved …
Dormant disseminated tumor cells and cancer stem/progenitor-like cells: Similarities and opportunities
Distant recurrences occurring years after removal of the primary tumor arise from
disseminated tumor cells (DTCs) that lie dormant (quiescent/asymptomatic) until they …
disseminated tumor cells (DTCs) that lie dormant (quiescent/asymptomatic) until they …
[HTML][HTML] Targeting cancer stem cells in drug discovery: Current state and future perspectives
FY Du, QF Zhou, WJ Sun, GL Chen - World journal of stem cells, 2019 - ncbi.nlm.nih.gov
In recent decades, cancer stem cells (CSCs) have been increasingly identified in many
malignancies. CSC-related signaling pathways and their functions provide new strategies …
malignancies. CSC-related signaling pathways and their functions provide new strategies …
Polycomb complexes in normal and malignant hematopoiesis
Epigenetic mechanisms are crucial for sustaining cell type–specific transcription programs.
Among the distinct factors, Polycomb group (PcG) proteins are major negative regulators of …
Among the distinct factors, Polycomb group (PcG) proteins are major negative regulators of …
Super-enhancers, phase-separated condensates, and 3D genome organization in cancer
SC Tang, U Vijayakumar, Y Zhang, MJ Fullwood - Cancers, 2022 - mdpi.com
Simple Summary Gene expression is primarily controlled at the level of transcription, largely
due to binding of transcription factors to specific sites on DNA, namely super-enhancers and …
due to binding of transcription factors to specific sites on DNA, namely super-enhancers and …
Developing targeted therapies that exploit aberrant histone ubiquitination in cancer
LMP Jeusset, KJ McManus - Cells, 2019 - mdpi.com
Histone ubiquitination is a critical epigenetic mechanism regulating DNA-driven processes
such as gene transcription and DNA damage repair. Importantly, the cellular machinery …
such as gene transcription and DNA damage repair. Importantly, the cellular machinery …
Polycomb-group proteins in the initiation and progression of cancer
X Zhao, X Wu - Journal of Genetics and Genomics, 2021 - Elsevier
Abstract The Polycomb group (PcG) proteins are a family of chromatin regulators and critical
for the maintenance of cellular identity. The PcG machinery can be categorized into at least …
for the maintenance of cellular identity. The PcG machinery can be categorized into at least …